Prospective double-blind study of effect of ketorolac administration after laparoscopic urologic surgery

Journal of Endourology
G K ChowL R Kavoussi

Abstract

To decrease postoperative dependence on narcotics for analgesia, we have evaluated ketorolac as an adjunct to perioperative pain control in patients undergoing laparoscopic urologic surgery. Sixty-five patients (34 male, 31 female) were randomized to receive either ketorolac tromethamine (15-30 mg IV q 6 h) or placebo prior to laparoscopic surgery. Patient-controlled analgesia in the form of morphine sulfate was provided. Operative factors such as the type of surgery, operative time, and estimated blood loss were recorded. Postoperative factors such as analog pain score (range 0-10), narcotic usage, and length of stay were evaluated. Fifty-five patients completed the study. The average pain score was 2.2 and 4.5 for the ketorolac and placebo groups, respectively (P < 0.005). The mean amounts of total morphine used were 39.2 mg (ketorolac) and 62.5 mg (placebo) (P = 0.077). The length of stay was not significantly different in the ketorolac (2.5 days) and placebo (2.6 days) groups (P = 0.74). Operative times (P = 0.21) and estimated blood loss (P = 0.60) were not significantly different in the two groups. Ketorolac did not adversely affect renal function; serum creatinine changes were not significantly different from those in th...Continue Reading

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Citations

Apr 3, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·James M FeldWilliam E Hoffman
Dec 14, 2012·Expert Review of Neurotherapeutics·Mario De Pinto, Alex Cahana
Aug 12, 2009·Expert Opinion on Drug Delivery·V R SinhaG Singh
Dec 3, 2011·Contraception·Natalie E RocheVasanti Tilak
Apr 18, 2014·Pain Practice : the Official Journal of World Institute of Pain·Nalini VadiveluJoseph V Pergolizzi
Sep 16, 2017·Female Pelvic Medicine & Reconstructive Surgery·Elisa R TrowbridgeKathie L Hullfish
Jan 24, 2012·Anesthesia and Analgesia·Paul F WhiteHenrik Kehlet
Oct 4, 2011·Anesthesia and Analgesia·Gildasio S De OliveiraHonorio T Benzon
Apr 16, 2021·Journal of Robotic Surgery·Laura HorodyskiLeslie A Deane

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