Prospective evaluation of CO2 laser-assisted sclerectomy surgery (CLASS) with Mitomycin C

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Carlo Alberto CutoloCarlo Enrico Traverso


Our purpose was to evaluate the clinical safety and efficacy of CO2 laser-assisted sclerectomy surgery (CLASS) with Mitomycin C (MMC) in open angle glaucoma (OAG). This was a prospective, uncontrolled, interventional case series. All subjects underwent CLASS procedure by a single surgeon. After the dissection of a partial thickness scleral flap, topical MMC 0.2 mg/ml was applied to the sclera and the conjunctiva for 3 min. The CO2 laser with a beam-manipulating system was used to ablate the scleral tissue and expose the Schlemm's canal area. Primary outcomes: intraocular pressure (IOP) change, number of IOP-lowering medicaments change. Adverse events were evaluated as secondary outcomes. Twenty-one eyes of 21 patients underwent the CLASS procedure. Thirteen were primary OAG (62%), two normal pressure glaucoma (10%), three exfoliative glaucoma (14%) and three others secondary OAG. With a mean (SD) follow-up of 15.3 (5.9) months, the IOP changed from 25.4 (6.7) mmHg at baseline to 10.9 (3.4) mmHg al the last visit. Mean reduction of IOP was -14.5 mmHg (95% CI, -17.7 to -11.2, P < 0.001). The median (IQR) number of IOP-lowering medication decreased from 3 (3-3) at baseline to 1 (0-1) at the last visit (P < 0.001). Visual acuity di...Continue Reading


Mar 18, 1999·Journal of Cataract and Refractive Surgery·A MermoudR Faggioni
Apr 20, 2001·Journal of Cataract and Refractive Surgery·C ArgentoJ Casiraghi
Jun 5, 2004·Journal of Cataract and Refractive Surgery·Tarek ShaarawyAndré Mermoud
Jun 9, 2005·American Journal of Ophthalmology·Henry D JampelUNKNOWN Collaborative Initial Glaucoma Treatment Study Group
Oct 24, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ehud I AssiaMichael Belkin
Nov 21, 2007·The British Journal of Ophthalmology·Irit BaharDavid Rootman
Feb 28, 2008·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Thomas KlinkFranz Grehn
Nov 26, 2008·Survey of Ophthalmology·Efstratios MendrinosTarek Shaarawy
Dec 19, 2008·Journal of Glaucoma·Alexandre BissigSylvain Roy
Mar 23, 2011·Journal of Glaucoma·Yokrat TonEhud I Assia
Sep 28, 2013·Ophthalmology·James F KirwanUNKNOWN Trabeculectomy Outcomes Group Audit Study Group
Mar 5, 2014·Journal of Glaucoma·Alon SkaatShlomo Melamed
Nov 11, 2014·Journal of Glaucoma·Gabriel GreifnerAndré Mermoud
Mar 22, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Marek RękasAnselm Jünemann

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