Prospective evaluation of endometrial thickness as a predictor of pituitary down-regulation after gonadotropin-releasing hormone analogue administration in an in vitro fertilization program

Fertility and Sterility
Amihai BarashZ Shoham

Abstract

To determine whether pituitary down-regulation after gonadotropin-releasing hormone analogue (GnRH-a) administration can be accurately predicted by transvaginal ultrasonographic measurement of endometrial thickness. Prospective study. An IVF unit of an academic medical center. One hundred eighty-one patients undergoing 265 IVF-ET treatment cycles using GnRH-a in the long protocol. Serum concentrations of E2 were determined, and endometrial thickness was measured by transvaginal sonography. The accuracy of endometrial thickness for predicting pituitary down-regulation was calculated. Pituitary down-regulation, defined as a serum E2 concentration of < or = 55 pg/mL, was achieved in 77% (204 of 265) of the cycles. An endometrial thickness of < or = 6 mm was found in 92.2% (188 of 204) of cycles in which down-regulation was achieved. An estradiol level of < or = 55 pg/mL was present in 95.9% (188 of 196) of cycles with endometrial thickness of < or = 6 mm. A state of relative hypoestrogenism after GnRH-a administration, indicative of pituitary down-regulation, can be predicted with a high degree of accuracy by ultrasonographic measurement of endometrial thickness. Thus, routine testing for serum E2 concentration may be safely omitt...Continue Reading

References

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Citations

May 17, 2013·Archives of Gynecology and Obstetrics·Ibrahim EsinlerLale Karakocsokmensuer
May 21, 2004·Reproductive Biomedicine Online·Muammer M DoganLeyla Mollamahmutoglu
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Jul 17, 2012·Gynecologic and Obstetric Investigation·Ibrahim EsinlerHakan Yarali
May 16, 2002·Reproductive Medicine and Biology·UNKNOWN AYUSTAWATIIkuo Sato

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