Prospective evaluation of intravitreal bevacizumab for ischemic central retinal vein occlusion

International Journal of Retina and Vitreous
Leangelo HallMaria Fernanda Abalem

Abstract

Although previous studies have evaluated the effect of anti-VEGF therapies for central retinal vein occlusion (CRVO) patients, the majority of previous studies have excluded or included a very small number of patients with ischemic CRVO (iCRVO). The aim of our study is to examine the effects of bevacizumab on macular edema secondary to ischemic central retinal vein occlusion, as well as the effects on central choroidal thickness and best-corrected visual acuity. In this prospective, interventional case series, iCRVO was defined by the presence of ≥ 10 or more disc diameter areas of retinal nonperfusion by fluorescein angiography (FA) and by the presence of a b/a ratio less than 1.5 by full-field electroretinogram (ffERG). Nine eyes with iCRVO received monthly bevacizumab 0.5 mg injections at baseline and months 1 to 5 for a maximum of six injections. Main outcome measures were visual acuity (Snellen), central foveal thickness, and central choroidal thickness as measured by Spectral-Domain Optical Coherence Tomography (SD-OCT) at baseline and at 6 month following initial intravitreal bevacizumab injection. Pairwise t-tests and the Wilcoxon signed-rank test were conducted to compare the outcome measures. After intravitreal admini...Continue Reading

References

Nov 11, 2008·Retina·Masafumi OtaNagahisa Yoshimura
May 1, 2010·Ophthalmology·Rachel L McIntoshTien Yin Wong
Aug 21, 2010·Ophthalmology·Sohan Singh HayrehM Bridget Zimmerman
May 24, 2011·Survey of Ophthalmology·Justis P Ehlers, Sharon Fekrat
Apr 13, 2012·Retina·Sohan Singh Hayreh, M Bridget Zimmerman
Apr 8, 2014·Clinical Ophthalmology·Erkan UnsalHülya Güngel
Jun 1, 2014·American Journal of Ophthalmology·Lei ShaoJost B Jonas

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