Prospective evaluation of radiation-induced skin toxicity in a race/ethnically diverse breast cancer population

Cancer Medicine
Jean L WrightJennifer J Hu

Abstract

We evaluated predictors of radiation-induced skin toxicity in a prospective study of a tri-racial/ethnic breast cancer population. We evaluated patient demographics, tumor characteristics, and treatment variables in the first 392 patients in a prospective study assessing radiation-induced skin toxicity. Logistic regression analyses were conducted to evaluate potential predictors of skin toxicity. The study consists of 59 non-Hispanic whites (NHW; 15%), 241 Hispanic Whites (HW; 62%), 79 black or African Americans (AA; 20%), and 13 others (3%). Overall, 48% developed grade 0-1 skin toxicity, 49.8% grade 2, and 2.2% grade 3 by the National Cancer Institute's Common Toxicity Criteria for Adverse Events (CTCAE) scale. Twenty-one percent developed moist desquamation. In multivariate analysis, higher body mass index (BMI; OR = 2.09; 95%CI = 1.15, 3.82), higher disease stage (OR = 1.82; 95%CI = 1.06, 3.11), ER-positive/PR-negative status (OR = 2.74; 95%CI = 1.26, 5.98), and conventionally fractionated regimens (OR = 3.25; 95%CI = 1.76, 6.01) were significantly associated with higher skin toxicity grade after adjustment for age, race, ethnicity, ER status, and breast volume. B MI specifically predicted for moist desquamation, but not de...Continue Reading

References

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Citations

Jul 11, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jennifer J HuEdward G Shaw
Sep 29, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Reshma JagsiUNKNOWN Michigan Radiation Oncology Quality Consortium
May 8, 2020·International Journal of Radiation Oncology, Biology, Physics·Anna M LaucisUNKNOWN Michigan Radiation Oncology Quality Consortium

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Methods Mentioned

BETA
dissection
biopsy

Software Mentioned

SAS
Eclipse

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