PMID: 7019410Jun 1, 1981Paper

Prospective evaluation of radionuclide scanning in detection of intestinal necrosis in neonatal necrotizing enterocolitis

Journal of Pediatric Surgery
G M HaaseE T Boles

Abstract

The ability of external imaging to demonstrate intestinal infarction in neonatal necrotizing enterocolitis (NEC) was prospectively evaluated. The radiopharmaceutical technetium--99m diphosphonate was injected intravenously and the patients subsequently underwent abdominal scanning. Clinical patient care and interpretation of the images were entirely independent throughout the study. Of 33 studies, 7 were positive, 4 were suspicious, and 22 were negative. One false positive study detected ischemia without transmural infarction. The second false positive scan occurred postoperatively and was due to misinterpretation of the hyperactivity along the surgical incision. None of the suspicious cases had damaged bowel. The two false negative studies clearly failed to demonstrate frank intestinal necrosis. The presence of very small areas of infarction, errors in technical settings, subjective interpretation of scans and delayed clearance of the radionuclide in a critically ill neonate may all limit the accuracy of external abdominal scanning. However, in spite of an error rate of 12%, it is likely that this technique will enhance the present clinical, laboratory, and radiologic parameters of patient management in NEC.

References

Jul 1, 1976·Investigative Radiology·D H SchimmelP B Hoffer
Dec 1, 1978·Journal of Pediatric Surgery·V N OrtizE T Boles
Jan 1, 1985·AJR. American Journal of Roentgenology·G N Sfakianakis, E Sfakianaki
May 1, 1974·The Journal of Surgical Research·A R MoossaP Hoffer
Feb 1, 1974·Radiology·F J BonteE M Stokely

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Citations

Apr 26, 1984·The New England Journal of Medicine·R M Kliegman, A A Fanaroff
Jun 1, 1986·Journal of Pediatric Surgery·S LindleyE S Golladay
Nov 1, 1987·Acta paediatrica Scandinavica·D IsaacsA R Wilkinson
Apr 5, 2005·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Sanjay Patole
Jul 16, 2003·Current Opinion in Infectious Diseases·Dimitris A KafetzisChristos Costalos
Apr 1, 1987·Current Problems in Pediatrics·R M Kliegman, M C Walsh

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