Prospective evaluation of subjects with chronic asymptomatic pancreatic hyperenzymemia

The American Journal of Gastroenterology
Antonio AmodioLuca Frulloni

Abstract

Chronic asymptomatic pancreatic hyperenzymemia (CAPH) has been described since 1996 as a benign disease. Recent studies described pathological findings at magnetic resonance cholangiopancreatography with secretin stimulation (s-MRCP) in more than half of the CAPH subjects. The aim of this study was to investigate the frequency and clinical relevance of s-MRCP findings in patients with CAPH. Subjects prospectively enrolled from January 2005 to December 2010 underwent s-MRCP and biochemical tests routinely performed. Data relative to 160 subjects (94 males, 66 females, age 49.6±13.6 years) were analyzed. In all, 51 (32%) subjects had hyperamylasemia, 9 (6%) hyperlipasemia, and 100 (62%) an increase in both enzyme levels. The time between the first increased dosage of serum pancreatic enzymes and our observation was 3.3±3.9 years (range: 1-15). Familial pancreatic hyperenzymemia was observed in 26 out of 133 subjects (19.5%). Anatomic abnormalities of the pancreatic duct system at s-MRCP were found in 24 out of 160 subjects (15%). Pathological MRCP findings were present in 44 subjects (27.5%) before and in 80 subjects (50%) after secretin administration (P<0.0001). Five subjects (3.1%) underwent surgery, 3 for pancreatic endocrine...Continue Reading

References

Mar 1, 1988·American Journal of Surgery·A L Warshaw, M M Hawboldt
Mar 9, 2000·Pancreas·L Gullo
Mar 22, 2001·Radiographics : a Review Publication of the Radiological Society of North America, Inc·J H LimY L Oh
Jan 18, 2002·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Celso MatosThierry Metens
Dec 5, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Lucio Gullo
Oct 6, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Joshua A WatersKeith D Lillemoe
Dec 2, 2008·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Alessandro GuariseAlec J Megibow
Mar 20, 2009·Scandinavian Journal of Gastroenterology·Raffaele PezzilliRoberto Corinaldesi

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Citations

Mar 19, 2016·Radiology·Riccardo Manfredi, Roberto Pozzi Mucelli
Jul 26, 2014·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·David GoodwinRodney Rouse
Dec 31, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Luca Frulloni, Antonio Amodio
Apr 5, 2013·The American Journal of Gastroenterology·Roberto ValenteGianfranco Delle Fave
Apr 5, 2013·The American Journal of Gastroenterology·Antonio Amodio, Luca Frulloni
Jun 13, 2018·Pancreas·Natalya B GubergritsTetiana S Alianova
Apr 5, 2019·Pancreas·Antonio AmodioLuca Frulloni
Jun 11, 2015·Pancreas·Marina Migliori, Roberto De Giorgio
Apr 20, 2014·Pancreas·Eleonora GalassiRoberto De Giorgio
Aug 29, 2018·Nutrients·Giulia De MarchiRachele Ciccocioppo
Apr 19, 2019·BMJ Case Reports·Caroline Annette Erika Bachmeier, Adam Morton
Dec 3, 2020·AJR. American Journal of Roentgenology·Jordan SwenssonTemel Tirkes
Mar 23, 2021·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Maria Cristina Conti BellocchiArmando Gabbrielli

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