Prospective evaluation of the Alere i Influenza A&B nucleic acid amplification versus Xpert Flu/RSV

Diagnostic Microbiology and Infectious Disease
J C Nguyen VanA Le Monnier

Abstract

The rapid and accurate detection of influenza virus in respiratory specimens is required for optimal management of patients with acute respiratory infections. Because of the variability of the symptoms and the numerous other causes of influenza-like illness, the diagnosis of influenza cannot be made on the basis of clinical criteria alone. Thus, rapid influenza diagnostic tests have been developed such as the Alere i Influenza A&B isothermal nucleic acid assay. We prospectively evaluated the performance of the Alere i Influenza A&B assay in comparison with our routine Xpert Flu/RSV assay. Positive samples were subtyped according to the protocol from the National Influenza Center (Paris, France). A total of 96 respiratory nasal swab samples were analyzed: with both methods, 38 were positive and 56 were negative. Samples were prospectively collected from January 20 to April 8, 2015, from patient (86 adult and 10 pediatric patients) presenting with an influenza-like illness through the French influenza season. In comparison with the Xpert Flu/RSV assay, the overall sensitivity and specificity of the Alere i Influenza A&B assay were 95% and 100%, respectively. Our results indicate that the Alere i Influenza A&B assay has a good ove...Continue Reading

References

Nov 5, 1997·The Pediatric Infectious Disease Journal·P M AdcockG S Marshall
Aug 12, 2009·Journal of Pain & Palliative Care Pharmacotherapy·UNKNOWN U.S. Food and Drug Administration
Mar 1, 2012·Annals of Internal Medicine·Caroline ChartrandMadhukar Pai
Mar 6, 2012·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Mark L MeterskyTimothy Babinchak
Jun 10, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L Leibovici, M Paul
Jul 6, 2014·Journal of Clinical Microbiology·Shuping NieN Esther Babady
Sep 26, 2014·Journal of Clinical Microbiology·Andrea F DugasRichard E Rothman
Dec 17, 2014·Journal of Clinical Microbiology·Kimberle C Chapin, Estefany J Flores-Cortez
Feb 7, 2015·BMC Infectious Diseases·Juan Carlos HurtadoJordi Vila Estape
Apr 2, 2015·The American Journal of Emergency Medicine·Andrea F DugasRichard E Rothman

❮ Previous
Next ❯

Citations

Aug 25, 2016·Mayo Clinic Proceedings·Robin Patel
Jun 12, 2018·Expert Review of Molecular Diagnostics·Catherine A HoganJesse Papenburg
Sep 2, 2016·Journal of Clinical Microbiology·Frederick S NolteSusan B Barrett
Feb 24, 2019·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Ji-Woon KimJae-Hong Kim
May 31, 2019·Journal of Clinical Microbiology·B A Pinsky, R T Hayden
Apr 22, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Eric FarfourMarc Vasse
Apr 25, 2018·Expert Review of Molecular Diagnostics·Hongmei WangYi-Wei Tang
Dec 20, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Timothy M UyekiAndrew T Pavia
Jul 7, 2019·International Journal of Environmental Research and Public Health·Roland Diel, Albert Nienhaus
Oct 21, 2018·Biosensors·Karolina DziąbowskaDawid Nidzworski
Feb 23, 2021·Biochip Journal·Hanbi KimMinhee Kang
Oct 2, 2019·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S Zidovec Lepej, M Poljak
Apr 16, 2021·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Eric FarfourUNKNOWN SARS-CoV-2 Foch Hospital study group
Apr 15, 2021·Diagnostic Microbiology and Infectious Disease·Ralph-Sydney Mboumba BouassaLaurent Bélec
Oct 12, 2016·Microbiology Spectrum·Richard L Hodinka
Nov 13, 2021·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Jean-Claude NguyenVanAlban Le Monnier

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.