Prospective evaluation of transcatheter arterial chemoembolization (TACE) with multiple anti-cancer drugs (epirubicin, cisplatin, mitomycin c, 5-fluorouracil) compared with TACE with epirubicin for treatment of hepatocellular carcinoma

Cardiovascular and Interventional Radiology
Shinya SaharaTetsuo Sonomura

Abstract

To compare the efficacy of transcatheter arterial chemoembolization (TACE) using multiple anticancer drugs (epirubicin, cisplatin, mitomycin C, and 5-furuorouracil: Multi group) with TACE using epirubicin (EP group) for hepatocellular carcinoma (HCC). The study design was a single-center, prospective, randomized controlled trial. Patients with unrespectable HCC confined to the liver, unsuitable for radiofrequency ablation, were assigned to the Multi group or the EP group. We assessed radiographic response as the primary endpoint; secondary endpoints were progression-free survival (PFS), safety, and hepatic branch artery abnormality (Grade I, no damage or mild vessel wall irregularity; Grade II, overt stenosis; Grade III, occlusion; Grades II and III indicated significant hepatic artery damage). A total of 51 patients were enrolled: 24 in the Multi group vs. 27 in the EP group. No significant difference in HCC patient background was found between the groups. Radiographic response, PFS, and 1- and 2-year overall survival of the Multi vs. EP group were 54% vs. 48%, 6.1 months vs. 8.7 months, and 95% and 65% vs. 85% and 76%, respectively, with no significant difference. Significantly greater Grade 3 transaminase elevation was found...Continue Reading

References

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Citations

Sep 27, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Wenting CaoZhixia Ye
Jun 17, 2014·Biological & Pharmaceutical Bulletin·Yoshitaka KanayamaYasuo Sakai
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Jun 23, 2020·Experimental Biology and Medicine·Zhiyong ShenWeixing Qu
Oct 26, 2021·Cardiovascular and Interventional Radiology·Pierleone LucatelliThomas Helmberger

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