Prospective Evaluation of Two iStent® Trabecular Stents, One iStent Supra® Suprachoroidal Stent, and Postoperative Prostaglandin in Refractory Glaucoma: 4-year Outcomes

Advances in Therapy
Jonathan S MyersL Jay Katz

Abstract

This study evaluates long-term outcomes of two trabecular micro-bypass stents, one suprachoroidal stent, and postoperative prostaglandin in eyes with refractory open angle glaucoma (OAG). Prospective ongoing 5-year study of 80 eligible subjects (70 with 4-year follow-up) with OAG and IOP ≥ 18 mmHg after prior trabeculectomy and while taking 1-3 glaucoma medications. Subjects received two iStent® trabecular micro-bypass stents, one iStent Supra® suprachoroidal stent, and postoperative travoprost. Postoperative IOP was measured with medication and annually following medication washouts. Performance was measured by the proportion of eyes with ≥ 20% IOP reduction on one medication (the protocol-specified prostaglandin) versus preoperative medicated IOP (primary outcome); and the proportion of eyes with postoperative IOP ≤ 15 and ≤ 18 mmHg on one medication (secondary outcome). Additional clinical and safety data included medications, visual field, pachymetry, gonioscopy, adverse events, visual acuity, and slit-lamp and fundus examinations. Preoperatively, mean medicated IOP was 22.0 ± 3.1 mmHg on 1.2 ± 0.4 medications, and mean unmedicated IOP was 26.4 ± 2.4 mmHg. Postoperatively, among eyes without later cataract surgery, mean med...Continue Reading

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Citations

Dec 24, 2018·Current Opinion in Ophthalmology·Sabita M IttoopMalik Y Kahook
Sep 17, 2020·Annual Review of Vision Science·David J Mathew, Yvonne M Buys
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Aug 3, 2020·Journal of Glaucoma·Arvi-Matti KuusniemiMika Harju
Jul 29, 2021·Acta Ophthalmologica·Michele FigusChiara Posarelli
Aug 19, 2021·Translational Vision Science & Technology·Eric MikulaTibor Juhasz

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Methods Mentioned

BETA
imaging techniques

Clinical Trials Mentioned

NCT01456390

Software Mentioned

iStent

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