PMID: 6970983Jan 1, 1980Paper

Prospective evaluation of vestibular and auditory function in 76 patients treated with netilmicin

Scandinavian Journal of Infectious Diseases. Supplementum
O Tjernström

Abstract

Seventy-six patients were included in a prospective study in order to assess the ototoxicity of netilmicin. Netilmicin. Netilmicin was administered intramuscularly with a dosage of 1.5 mg/kg body weight 2 or 3 times daily. The dosage was modified in cases with even slight renal insufficiency. Vestibular and auditory function was examined by electronystagmography (ENG) and audiometry before and during therapy, 1 week and 2-3 months after completion of therapy. Drug-related VIIIth nerve toxicity--vestibular dysfunction--was suspected in one case. However, this dysfunction was subclinical and reversible. The importance of pretreatment evaluation was obvious as an ototoxic damage might have been suspected in 14 patients if the pretreatment examination of vestibular and auditory function had not been performed. Clinical ototoxicity of netilmicin seems to be low when careful attention is paid to the renal function and the serum concentrations of the drug.

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Related Papers

Acta Oto-laryngologica
O TjernströmN G Toremalm
The Journal of International Medical Research
L NordströmE Wallmark
Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
B S GendehZ M Zahir
© 2021 Meta ULC. All rights reserved