PMID: 11929370Apr 4, 2002Paper

Prospective identification and treatment of children with pediatric autoimmune neuropsychiatric disorder associated with group A streptococcal infection (PANDAS)

Archives of Pediatrics & Adolescent Medicine
Marie Lynd Murphy, Michael E Pichichero

Abstract

The current diagnostic criteria for pediatric autoimmune neuropsychiatric disorder associated with group A streptococcal infection (PANDAS) are pediatric onset, neuropsychiatric disorder (obsessive-compulsive disorder [OCD]) and/or tic disorder; abrupt onset and/or episodic course of symptoms; association with group A beta-hemolytic streptococcal (GABHS) infection; and association with neurological abnormalities (motoric hyperactivity or adventitious movements, including choreiform movements or tics). To assess new-onset PANDAS cases in relation to acute GABHS tonsillopharyngitis. Prospective PANDAS case identification and follow-up. Over a 3-year period (1998-2000), we identified 12 school-aged children with new-onset PANDAS. Each patient had the abrupt appearance of severe OCD behaviors, accompanied by mild symptoms and signs of acute GABHS tonsillopharyngitis. Throat swabs tested positive for GABHS by rapid antigen detection and/or were culture positive. The GABHS serologic tests, when performed (n = 3), showed very high antideoxyribonuclease antibody titers. Mean age at presentation was 7 years (age range, 5-11 years). In children treated with antibiotics effective in eradicating GABHS infection at the sentinel episode, OCD...Continue Reading

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Citations

Jul 9, 2013·Indian Journal of Psychological Medicine·Naren P RaoJanardhan Y C Reddy
Aug 26, 2014·The Psychiatric Clinics of North America·Tanya K MurphyJames F Leckman
Feb 11, 2011·Current Infectious Disease Reports·Sheila Knupp Feitosa de Oliveira, Christina Feitosa Pelajo
Oct 16, 2014·Indian Journal of Psychiatry·Praveen Navkhare, Gurvinder Kalra
Aug 6, 2014·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Marco PozziEmilio Clementi
Jun 24, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S EspositoD Rigante
Jun 9, 2014·Social Psychiatry and Psychiatric Epidemiology·Cornelia WitthauerRoselind Lieb
Jun 24, 2004·Archives of Disease in Childhood·R C DaleB G R Neville
Jan 25, 2005·Infection and Immunity·Björn ZimmerleinP Patrick Cleary
May 23, 2008·Clinical Practice and Epidemiology in Mental Health : CP & EMH·Germana MorettiMassimo Biondi
Oct 8, 2008·Development and Psychopathology·Tiago V MaiaBradley S Peterson
Sep 1, 2009·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M S GableC A Glaser
Apr 1, 2006·Indian Journal of Psychiatry·Chittaranjan Andrade, N Pfizer
Feb 2, 2013·Indian Journal of Psychiatry·Baljeet MainiPrem D Sharma
Jul 15, 2003·Current Psychiatry Reports·Paul ArnoldDavid R Rosenberg
Feb 25, 2005·Advances in Therapy·Alexander K C Leung, James D Kellner
Feb 13, 2016·Journal of Child and Adolescent Psychopharmacology·Yangsik KimHyo-Won Kim
Feb 4, 2012·Comprehensive Psychiatry·Leonardo F FontenelleAntonio Lucio Teixeira
Apr 20, 2010·Pediatric Neurology·I-Ching ChouFuu-Jen Tsai
Nov 17, 2009·Journal of Psychosomatic Research·Davide MartinoGavin Giovannoni
May 12, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Vilma GabbayCharles J Gonzalez
Mar 3, 2009·The Psychiatric Clinics of North America·Andrea M Victor, Gail A Bernstein
Jan 14, 2009·Journal of Affective Disorders·Giuseppe MainaMaria Claudia Vigliani
Feb 12, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Felipe Filardi da RochaAntonio Lucio Teixeira
Apr 4, 2007·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Francesco CardonaGraziella Orefici
May 3, 2006·The Psychiatric Clinics of North America·Tanya K MurphyWayne K Goodman
Mar 10, 2005·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Susan E Swedo, Paul J Grant
Apr 9, 2010·International Journal of Rheumatic Diseases·Nazgul A OmurzakovaToshihiro Nakajima
Jul 15, 2009·Journal of the American Academy of Nurse Practitioners·Rebecca Sturm
Apr 9, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Davide MartinoJames F Leckman
Jun 23, 2010·Journal of Clinical Apheresis·Zbigniew M SzczepiorkowskiUNKNOWN Apheresis Applications Committee of the American Society for Apheresis
Dec 2, 2004·Psychiatry Research·Eric A StorchWayne K Goodman
Dec 14, 2004·Psychiatry Research·Norbert MüllerMarianne Abele-Horn
Sep 28, 2006·Journal of the American Academy of Child and Adolescent Psychiatry·Eric A StorchWayne K Goodman
Oct 22, 2005·Journal of the American Academy of Child and Adolescent Psychiatry·Josephine EliaSusmita Pati
Sep 21, 2005·Child and Adolescent Psychiatric Clinics of North America·Henrietta L LeonardJanet S Ng
May 17, 2006·Anaerobe·Bennett Lorber

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