Existing therapies for prostate cancer eradicates the bulk of cells within a tumor. However, most patients go on to develop androgen-independent disease that remains incurable by current treatment strategies. There is now increasing evidence in some malignancies that the tumor cells are organized as a hierarchy originating from rare stem cells that are responsible for maintaining the tumor. We report here the identification and characterization of a cancer stem cell population from human prostate tumors, which possess a significant capacity for self-renewal. These cells are also able to regenerate the phenotypically mixed populations of nonclonogenic cells, which express differentiated cell products, such as androgen receptor and prostatic acid phosphatase. The cancer stem cells have a CD44+/alpha2beta1hi/CD133+ phenotype, and we have exploited these markers to isolate cells from a series of prostate tumors with differing Gleason grade and metastatic states. Approximately 0.1% of cells in any tumor expressed this phenotype, and there was no correlation between the number of CD44+/alpha2beta1hi/CD133+ cells and tumor grade. The identification of a prostate cancer stem cell provides a powerful tool to investigate the tumorigenic ...Continue Reading
Androgen and oestrogen responsiveness of stromal cells derived from the human hyperplastic prostate: oestrogen regulation of the androgen receptor
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
Differential expression of the mismatch repair gene hMSH2 in malignant prostate tissue is associated with cancer recurrence
Intermediate cells in normal and malignant prostate epithelium express c-MET: implications for prostate cancer invasion
The Sca-1 cell surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesis
Survival of mammary stem cells in suspension culture: implications for stem cell biology and neoplasia
Role of androgen receptors in hormone-refractory prostate cancer: molecular basics and experimental therapy approaches
The construction of an oxalate-degrading intestinal stem cell population in mice: a potential new treatment option for patients with calcium oxalate calculus
Breast cancer cells expressing stem cell markers CD44+ CD24 lo are eliminated by Numb-1 peptide-activated T cells
Expression of CD133 in the cytoplasm is associated with cancer progression and poor prognosis in gastric cancer
The stem cell marker prominin-1/CD133 interacts with vascular endothelial growth factor and potentiates its action
Functions of tumorigenic and migrating cancer progenitor cells in cancer progression and metastasis and their therapeutic implications
Adhesion molecules and chemokines: the navigation system for circulating tumor (stem) cells to metastasize in an organ-specific manner
Invasive prostate cancer cells are tumor initiating cells that have a stem cell-like genomic signature
Characterization and functional analysis of a slow cycling stem cell-like subpopulation in pancreas adenocarcinoma.
CD133(+) single cell-derived progenies of colorectal cancer cell line SW480 with different invasive and metastatic potential
A novel mouse CD133 binding-peptide screened by phage display inhibits cancer cell motility in vitro
Long-term cultures of stem/progenitor cells from lobular and ductal breast carcinomas under non-adherent conditions
Caffeic Acid Phenethyl Ester (CAPE) derived from propolis, a honeybee product, inhibits growth of breast cancer stem cells.
Immunohistochemical detection of CD133 is associated with tumor regression grade after chemoradiotherapy in rectal cancer.
Whole genome expression profiling reveals a significant role for the cell junction and apoptosis pathways in breast cancer stem cells
Screening of peptides bound to breast cancer stem cell specific surface marker CD44 by phage display
Adult Stem Cells
Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.