Prospective investigation of stress inoculation in young monkeys

Archives of General Psychiatry
Karen J ParkerD M Lyons

Abstract

Retrospective studies in humans have identified characteristics that promote stress resistance, including childhood exposure to moderately stressful events (ie, stress inoculation). Because of limited opportunities for prospective studies in children, we tested whether exposure to moderate stress early in life produces later stress resistance in a primate model. Twenty squirrel monkeys were randomized to intermittent stress inoculation (IS; n = 11) or a nonstress control condition (NS; n = 9) from postnatal weeks 17 to 27. At postnatal week 35, each mother-offspring dyad underwent testing in a moderately stressful novel environment for inferential measures of offspring anxiety (ie, maternal clinging, mother-offspring interactions, object exploration, and food consumption) and stress hormone concentrations (corticotropin [ACTH] and cortisol). At postnatal week 50, after acclimation to an initially stressful wire-mesh box attached to the home cage, independent young monkeys underwent testing for inferential measures of anxiety (ie, voluntary exploration and play) in the box. In the novel environment test, IS compared with NS offspring demonstrated diminished anxiety as measured by decreased maternal clinging (P =.02), enhanced ex...Continue Reading

Citations

Feb 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Karen J ParkerDavid M Lyons
Dec 19, 2012·Annual Review of Clinical Psychology·Edith Chen, Gregory E Miller
May 21, 2009·Nature Reviews. Neuroscience·Adriana FederDennis S Charney
Jun 24, 2009·Developmental Neuroscience·Maor KatzDavid M Lyons
Oct 25, 2011·Development and Psychopathology·Martie L SkinnerRichard F Catalano
Mar 13, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lin SuoLin Lu
Jul 17, 2008·Current Psychiatry Reports·Fatih OzbaySteven Southwick
Jan 22, 2013·Journal of Neural Transmission·Brigitte SchmidManfred Laucht
May 9, 2012·Development and Psychopathology·Michael Rutter
May 9, 2012·Development and Psychopathology·Christian E WaughIan H Gotlib
Oct 16, 2012·Development and Psychopathology·Julia Kim-Cohen, Rebecca Turkewitz
Apr 27, 2012·Nature Neuroscience·Richard J Davidson, Bruce S McEwen
Oct 16, 2012·Nature Neuroscience·Scott J RussoEric J Nestler
Jun 11, 2005·Psychoneuroendocrinology·Karen J ParkerDavid M Lyons
Feb 10, 2016·Current Opinion in Behavioral Sciences·Jeffrey A French, Sarah B Carp
Dec 18, 2013·Neuroscience·A S Zannas, A E West
Feb 18, 2016·Neural Plasticity·Archana AshokanRupshi Mitra
Apr 23, 2011·Neuroscience and Biobehavioral Reviews·Andrew Sih
May 31, 2011·Journal of the American Academy of Child and Adolescent Psychiatry·Isabelle Ouellet-MorinLouise Arseneault
Feb 1, 2011·Journal of Psychiatric Research·Merida M GrantRichard Shelton
Oct 14, 2010·Psychoneuroendocrinology·Klaus V WagnerMathias V Schmidt
Sep 21, 2010·Neuroscience and Biobehavioral Reviews·Karen J Parker, Dario Maestripieri
Feb 26, 2016·Applied Animal Behaviour Science·Hayley Ash, Hannah M Buchanan-Smith
Oct 5, 2007·Psychoneuroendocrinology·Daphne SimeonLisa M Smith
Jul 3, 2007·Psychoneuroendocrinology·Karen J ParkerDavid M Lyons
Mar 27, 2007·Hormones and Behavior·Miki BlochEhud Klein
Jun 17, 2014·Clinical Psychology Review·Christian E Waugh, Ernst H W Koster
Jul 2, 2009·Depression and Anxiety·Michael D EdgeJames J Gross
Aug 28, 2007·Journal of Traumatic Stress·David M Lyons, Karen J Parker
May 27, 2009·Child Development·Rina D EidenDouglas A Granger
Oct 20, 2010·Developmental Psychobiology·David M LyonsAlan F Schatzberg
Oct 7, 2009·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Isabelle Ouellet-MorinSylvana M Côté
Sep 17, 2013·Developmental Psychobiology·Melissa J HaganLinda J Luecken
Feb 23, 2010·Developmental Psychobiology·David M LyonsAlan F Schatzberg
Aug 21, 2014·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Benjamin HingJames B Potash
Apr 12, 2005·Biological Psychiatry·Karen J ParkerDavid M Lyons
Sep 15, 2006·Behavioural Brain Research·Cosette FoxCatherine Harrison
Apr 12, 2016·Development and Psychopathology·Daniel BerryUNKNOWN Family Life Project Key Investigators

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