Prospective long-term outcomes of a cohort of Ugandan children with laboratory monitoring during antiretroviral therapy

The Pediatric Infectious Disease Journal
Adeodata KekitiinwaFrank M Graziano

Abstract

Treatment of HIV-1 infected Ugandan children with antiretroviral therapy (ART) is increasing, but few prospective long-term studies evaluating the treatment process have been reported. In this study, we sought to determine prospectively how consistent monitoring of HIV-1 RNA levels affects the ART treatment process. One hundred eight children initiating ART were enrolled into this study. These children had comprehensive laboratory monitoring, including HIV-1 RNA level determination and genotype analysis (where appropriate), CD4% plus absolute counts and safety laboratory measurements performed before starting therapy and at regular intervals after receiving ART. Kaplan-Meier statistics were used to examine predictors of survival and virologic failure. Viral genotype analysis was performed on samples obtained from children having virologic failure to determine the emergence of mutations. Clinically, there was no difference in the 3-year survival between our cohort receiving consistent laboratory monitoring and a matched historical clinic cohort not routinely receiving laboratory monitoring. However, 34% of children receiving ART demonstrated virologic failure. Eleven of these children received second-line ART, and all responded ...Continue Reading

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Citations

May 25, 2013·The Journal of Infectious Diseases·Felicity FitzgeraldDiana Gibb
Jul 25, 2015·Expert Review of Anti-infective Therapy·Mohammad-Ali JenabianLaurent Bélec
Mar 31, 2015·AIDS Research and Human Retroviruses·Bhavna H ChohanGrace John-Stewart
Dec 6, 2014·The Pediatric Infectious Disease Journal·Torsak BunupuradahUNKNOWN Pediatric PROGRESS Study Team
Oct 19, 2016·The Pediatric Infectious Disease Journal·Felix Cyamatare RwabukwisiNeil Gupta

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