Prospective longitudinal study of subcortical brain volumes in individuals at high familial risk of mood disorders with or without subsequent onset of depression

Psychiatry Research. Neuroimaging
M PapmeyerA M McIntosh

Abstract

Subcortical volumetric brain abnormalities have been observed in mood disorders. However, it is unknown whether these reflect adverse effects predisposing to mood disorders or emerge at illness onset. Magnetic resonance imaging was conducted at baseline and after two years in 111 initially unaffected young adults at increased risk of mood disorders because of a close family history of bipolar disorder and 93 healthy controls (HC). During the follow-up, 20 high-risk subjects developed major depressive disorder (HR-MDD), with the others remaining well (HR-well). Volumes of the lateral ventricles, caudate, putamen, pallidum, thalamus, hippocampus and amygdala were extracted for each hemisphere. Using linear mixed-effects models, differences and longitudinal changes in subcortical volumes were investigated between groups (HC, HR-MDD, HR-well). There were no significant differences for any subcortical volume between groups controlling for multiple testing. Additionally, no significant differences emerged between groups over time. Our results indicate that volumetric subcortical brain abnormalities of these regions using the current method appear not to form familial trait markers for vulnerability to mood disorders in close relative...Continue Reading

References

Jun 20, 2002·Bipolar Disorders·John L Beyer, K Ranga R Krishnan
Jul 2, 2002·The American Journal of Psychiatry·Thomas FrodlHans-Jürgen Möller
May 14, 2003·Archives of General Psychiatry·Peter McGuffinAlastair Cardno
Aug 30, 2003·Biological Psychiatry·Mary L PhillipsRichard Lane
Aug 30, 2003·Biological Psychiatry·Mary L PhillipsRichard Lane
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Nov 6, 2003·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Jordan W Smoller, Christine T Finn
Jul 15, 2004·Annals of the New York Academy of Sciences·Jay N Giedd
Sep 15, 2004·Biological Psychiatry·Colm McDonaldNoel Kennedy
Jul 20, 2005·Bipolar Disorders·Manon Hj HillegersWillem A Nolen
Sep 3, 2008·Archives of General Psychiatry·Matthew J KemptonPaul M Grasby
May 12, 2009·Neuroscience and Biobehavioral Reviews·Jonathan Savitz, Wayne C Drevets
Sep 2, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Danilo ArnoneA M McIntosh
Dec 18, 2009·Biological Psychiatry·Uma RaoConstance L Hammen
Jan 26, 2010·Journal of Psychiatric Research·William F C BaaréLars Vedel Kessing
Feb 18, 2010·Human Brain Mapping·Rajendra A MoreyGregory McCarthy
Oct 23, 2010·Journal of Psychiatry & Neuroscience : JPN·Francesco AmicoThomas Frodl
Nov 3, 2010·The British Journal of Psychiatry : the Journal of Mental Science·Anne Duffy
Mar 25, 2011·Biological Psychiatry·Emma SprootenAndrew M McIntosh
Jul 5, 2011·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·D ArnoneI M Anderson
Jul 6, 2011·Archives of General Psychiatry·Matthew J KemptonSteven C R Williams
Aug 17, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sonia J LupienJean R Séguin
Feb 3, 2012·Journal of Psychiatry & Neuroscience : JPN·Paolo Fusar-PoliStefan Borgwardt
Mar 13, 2012·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Thomas G SchulzeFrancis J McMahon
Aug 8, 2012·Psychiatry Research·Karim SalehThomas Frodl
Mar 1, 2014·The American Journal of Psychiatry·Sarah WhittleNicholas B Allen
Jul 9, 2014·NeuroImage. Clinical·Nina Romanczuk-SeiferthAndreas Heinz

❮ Previous
Next ❯

Citations

Apr 19, 2017·The Australian and New Zealand Journal of Psychiatry·Andrea PfennigMichael Bauer
Mar 27, 2018·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Marieke G N BosChristian K Tamnes
Dec 19, 2017·Journal of Geriatric Psychiatry and Neurology·Natalie J Sachs-EricssonDavid C Steffens
Nov 21, 2019·Molecular Psychiatry·Mitzy KennisClaudi Bockting
Mar 24, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Yara J ToendersLianne Schmaal

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques

Software Mentioned

FreeSurfer
stats
R
SPSS

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.