Abstract
Presence of circulating donor-specific antibodies (DSA) may be associated with worse clinical outcomes after intestine/multivisceral transplantation. In 79 intestine/multivisceral recipients, sera were prospectively screened for DSA by Luminex Single antigen test at 1, 3, 6, 9, 12, 18, 24, and 36 months after transplantation. Standard immunosuppression included thymoglobulin-rituximab induction and tacrolimus-prednisone maintenance. C4d staining was performed retrospectively on biopsies in patients that developed acute rejection (AR). Twenty-two (28%) patients developed de novo DSA at a median posttransplant period of 3 (1-36) months. De novo DSA were observed in 10 of 40 liver-including and 12 of 39 liver-excluding transplants (P = 0.57). Occurrence of AR was slightly higher in patients with de novo DSA (45% vs 33%, respectively; P = 0.41). Similarly, chronic rejection (14% vs 5%; P = 0.21) and graft loss due to AR (18% vs 7%; P = 0.14) were numerically higher in patients with de novo DSA. Only 35% patients experiencing AR had circulating de novo DSA at the time of AR. Antibody-mediated rejection was diagnosed in 6 patients based on C4d staining, of these 2 patients had circulating de novo DSA at the time of biopsy. De novo DS...Continue Reading
References
Feb 1, 1992·Seminars in Liver Disease·A J DemetrisJ J Fung
May 8, 2000·Transplantation·H M Gebel, R A Bray
Jan 11, 2000·Clinical Transplantation·A L LobashevskyJ M Thomas
Sep 28, 2001·Archives of Surgery·D G FarmerR W Busuttil
Mar 27, 2003·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Maria ParizhskayaKareem Abu-Elmagd
Mar 31, 2004·Transplantation Proceedings·P RuizJ Reyes
May 1, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·N Patey-Mariaud de SerreO Goulet
May 14, 2008·Transplantation·Rodrigo M ViannaJoseph Tector
Jun 27, 2008·Transplantation·Rodrigo M ViannaJoseph Tector
Jul 23, 2008·Transplantation·Richard S MangusRodrigo M Vianna
Oct 29, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Kareem M Abu-ElmagdGeorge Mazariegos
Apr 21, 2009·Human Immunology·Peter StastnyBhavna Lavingia
May 9, 2009·Transplantation·Gunnar TydénLars Mjörnstedt
Sep 25, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A LoupyD Nochy
Mar 23, 2010·Transplant Immunology·A LobashevskyN Higgins
Nov 26, 2010·Transplantation Proceedings·R J GraffK L Lentine
Jan 29, 2011·Nephrology·William R Mulley, John Kanellis
Aug 2, 2011·Transplantation·Hsin-Lin TsaiAndreas G Tzakis
Sep 13, 2011·Transplant Immunology·Sharif AliMary Ann Y Huang
Mar 21, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C WiebeP W Nickerson
Sep 6, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K M Abu-ElmagdA Zeevi
Dec 15, 2012·Transplantation·Benjamin J SwansonStanley J Radio
Feb 26, 2013·Transplantation·Chandrashekhar A KubalA Joseph Tector
Sep 14, 2013·Transplantation·Chandrashekhar A KubalA Joseph Tector
Oct 10, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T BacheletJ-L Taupin
Nov 28, 2013·Transplant International : Official Journal of the European Society for Organ Transplantation·Undine A GerlachAndreas Pascher
Citations
Jan 8, 2016·Current Opinion in Organ Transplantation·Augusto LauroCal S Matsumoto
May 21, 2016·Current Opinion in Organ Transplantation·Maria P BettinottiMary S Leffell
Sep 21, 2016·Current Gastroenterology Reports·Alexander KroemerThomas M Fishbein
Nov 8, 2016·Frontiers in Immunology·Yoshiko Matsuda, Minnie M Sarwal
Feb 6, 2017·Current Opinion in Organ Transplantation·Elaine Y ChengDouglas G Farmer
Aug 5, 2016·Transplantation·Elaine Y ChengDouglas G Farmer
Jan 29, 2017·Gastroenterology Report·Shishira BharadwajKareem Abu-Elmagd
Nov 19, 2017·Transplant International : Official Journal of the European Society for Organ Transplantation·Annemarie WeissenbacherSusan V Fuggle
Aug 17, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Paloma TalayeroEsther Mancebo
Jan 30, 2019·Current Opinion in Organ Transplantation·Jason S Hawksworth, Cal S Matsumoto
Jun 25, 2019·International Reviews of Immunology·Laura J Wozniak, Robert S Venick
Mar 1, 2018·Terapevticheskiĭ arkhiv·A I ParfenovT N Kuzmina
Jan 13, 2018·Digestive Diseases and Sciences·Augusto LauroIgnazio R Marino
Feb 22, 2018·Current Opinion in Organ Transplantation·Armando GanozaGeorge V Mazariegos
Feb 20, 2019·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Augusto Lauro, Ignazio R Marino
Mar 11, 2017·Current Opinion in Gastroenterology·Larry LooPhilip Allan
Dec 31, 2020·Pediatric Transplantation·Hanh D VoTeri J Mauch
Oct 24, 2020·Journal of Pediatric Gastroenterology and Nutrition·Abdalla Kara BallaStuart S Kaufman
Jan 8, 2021·Current Opinion in Organ Transplantation·Robert S Venick
Feb 3, 2021·Current Opinion in Organ Transplantation·Cal S Matsumoto, Sandra Rosen-Bronson
Apr 20, 2021·Clinical Transplantation·Qingyong XuAdriana Zeevi
May 27, 2021·Transplantation Direct·Hiroyuki TakamatsuShinji Nakao
Apr 25, 2017·Journal of Visceral Surgery·A LauroK R Iyer