Prospective morbidity and mortality assessment of cytoreductive surgery plus perioperative intraperitoneal chemotherapy to treat peritoneal dissemination of appendiceal mucinous malignancy

Annals of Surgical Oncology
Paul H SugarbakerDavid Chang

Abstract

Appendiceal mucinous neoplasms present, in most patients, with peritoneal dissemination at the time of initial diagnosis. Patients may have a borderline tumor showing disseminated peritoneal adenomucinosis or an aggressive malignancy identified as peritoneal mucinous adenocarcinoma. Patients with these diagnoses were treated by cytoreductive surgery and perioperative intraperitoneal chemotherapy. A database was established in 1998 that prospectively evaluated the morbidity and mortality of this group of patients. By using common toxicity grading criteria, 8 categories were scored on a grade of I to V. Grade IV indicated that the adverse event required urgent and definitive intervention: often a return to the operating room or to the surgical intensive care unit. Grade V indicated that the adverse events resulted in the patient's death. Adverse events were tabulated for each cytoreduction performed in these appendiceal malignancy patients. There were 356 procedures in patients taken to the operating room who received cytoreductive surgery with peritonectomy procedures plus heated intraoperative intraperitoneal chemotherapy. Only patients who had this combined treatment at our institution were included in the analysis. The total ...Continue Reading

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Citations

Aug 31, 2013·Annals of Surgical Oncology·Edmund K BartlettGiorgos C Karakousis
Mar 1, 2014·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Parissa TabrizianDaniel M Labow
May 28, 2014·Journal of Oncology·Horacio N López-BasaveAbelardo Meneses Garcia
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May 29, 2009·Annals of Surgical Oncology·Laura A LambertPaul F Mansfield
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Aug 22, 2007·Annals of Surgical Oncology·Edward A Levine
Feb 4, 2012·Annals of Surgical Oncology·Frances AustinHaroon A Choudry
Mar 5, 2013·Annals of Surgical Oncology·Patrick L WagnerHaroon A Choudry
Oct 9, 2013·Annals of Surgical Oncology·Francis S W ZihCarol J Swallow
May 31, 2012·Abdominal Imaging·Dhakshina Moorthy GaneshanPriya Bhosale
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Oct 2, 2012·Surgical Oncology Clinics of North America·Konstantinos I VotanopoulosEdward A Levine
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