Prospective multicenter observational trial on the safety and efficacy of LEVORAG® Emulgel in the treatment of acute and chronic anal fissure

Techniques in Coloproctology
R DigennaroD F Altomare

Abstract

Anal fissure (AF) is a common cause of anal pain with a tendency not to heal spontaneously because of ischemia of the anoderm caused by sphincter spasm. Lateral internal sphincterotomy, while very effective, can cause fecal incontinence and chemical sphincterotomy by application of cream may have discouraging side effects and/or low efficacy. The aim of this prospective multicenter study was to evaluate the safety and effectiveness of a new medical treatment based on Emulgel cream, with emollient, soothing and protective agents, on AF healing. Consecutive patients with AF treated in nine coloproctology units during 6 months entered the study on topical treatment with Levorag(®) Emulgel (THD S.p.A Correggio (RE), Italy). Before treatment, they had a proctologic examination and pain was measured using a visual analog scale. THD Levorag(®) Emulgel was applied every 12 h for 40 days. Monitoring was scheduled at 10, 20 and 40 days. At time 0 and at the end of treatment, patients underwent anorectal manometry, if possible. Two hundred eighty-four AF patients were recruited (171 acute fissures). Complete healing was achieved in 47.9 % of the cases, an improvement in 31.0 % (global efficacy 78.9 %). In patients with acute fissure, the ...Continue Reading

References

Jul 1, 1994·Diseases of the Colon and Rectum·W R SchoutenJ J Auwerda
Oct 1, 1996·The British Journal of Surgery·J N Lund, J H Scholefield
Oct 29, 2008·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·K L R CrossUNKNOWN ACPGBI
May 4, 2011·Techniques in Coloproctology·D F AltomareR D Villani
Aug 2, 2011·International Journal of Colorectal Disease·Avi LevinJoseph Lysy
Jan 27, 2012·Techniques in Coloproctology·L ZorcoloG Casula
Mar 16, 2013·World Journal of Gastrointestinal Surgery·Akira TsunodaNobuyasu Kano
Dec 20, 2013·Pakistan Journal of Medical Sciences·Ansar LatifMuhammad Qasim Butt

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Citations

Jul 27, 2017·Khirurgiia·N N Krylov, L V Lyatifova
Apr 24, 2017·Updates in Surgery·J MartellucciI Giani
Jan 26, 2020·International Journal of Colorectal Disease·Andreas Nordholm-CarstensenPeter-Martin Krarup
Aug 11, 2020·Minerva chirurgica·Benedetto Di TrapaniGiovanni Tomasello
Sep 18, 2021·World Journal of Emergency Surgery : WJES·Antonio TarasconiFausto Catena

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