Prospective observations of emerging psychosis

The Journal of Nervous and Mental Disease
Joanna L RosenThomas H McGlashan

Abstract

Because delays in treatment of psychosis may be associated with poorer outcomes, intervention focus has shifted to the prodromal phase of illness. However, knowledge about this phase has been limited to retrospective reconstructions of symptoms once psychosis is already present. The following article offers a new, prospective view of the development of schizophrenia starting from the late prodromal phase of illness. As we use the term, late prodromal phase of illness means at imminent risk of conversion to schizophrenia. In this article, entry, conversion, and discharge data are presented on a sub-population of eight patients who received treatment for psychosis at onset while participating in a prospective double-blind placebo-controlled treatment study of the prodrome to psychosis. Through disguised case examples, this article then focuses on the course of illness progression in three of eight cases who converted to schizophreniform psychosis while randomized on either active medication or placebo. Discussion focuses on the dimensional quality of the transition both from the prodrome to psychosis and from psychosis to recovery.

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Citations

Mar 9, 2005·Archives of General Psychiatry·Rajendra A MoreyAysenil Belger
Jan 31, 2004·American Journal of Preventive Medicine·Michael T Compton
May 8, 2007·Schizophrenia Bulletin·Thomas H McGlashanAlison Yung
Jun 30, 2005·Journal of Psychiatric Practice·Lisa J PhillipsPatrick D McGorry
Sep 15, 2006·The Journal of Nervous and Mental Disease·Sarah UzelacCristina Gonzales
Jan 30, 2003·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Aaron W GrossmanWilliam T Greenough
Oct 8, 2013·Schizophrenia Research·Jessica R Lunsford-AveryVijay A Mittal
Jul 19, 2011·Schizophrenia Research·Elizabeth JacobsJason Schiffman
Feb 26, 2004·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Joan Rosenbaum AsarnowEmily P McGrath
Feb 1, 2008·Early Intervention in Psychiatry·Harriet WoodsideKaren Pocock
Apr 28, 2006·Acta Psychiatrica Scandinavica·K A Olsen, B Rosenbaum
Nov 1, 2007·Early Intervention in Psychiatry·Thomas H McGlashan
Apr 10, 2003·The Psychiatric Clinics of North America·Mary Clarke, Eadbhard O'Callaghan
Mar 22, 2018·The Journal of Nervous and Mental Disease·Michael D MasucciRagy R Girgis
Jun 29, 2018·Psychological Medicine·Adam J CiarleglioRagy R Girgis
Feb 12, 2019·Development and Psychopathology·Hannah C ChapmanGregory P Strauss
Nov 7, 2019·The Cochrane Database of Systematic Reviews·Dina Bosnjak KuharicLivia Puljak
Jun 17, 2011·The Cochrane Database of Systematic Reviews·John BolaHaluk Soydan
Apr 14, 2021·Psychiatry Research. Neuroimaging·Ragy R GirgisFrank A Provenzano

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