PMID: 9165509Apr 1, 1997Paper

Prospective, open-label, add-on study of lamotrigine in 56 children with intractable generalized epilepsy

Pediatric Neurology
K FarrellL M MacWilliam

Abstract

The role of lamotrigine (LTG) in childhood epilepsy is emerging. We evaluated the efficacy and adverse effects of LTG in an open, prospective study of 56 children with generalized epilepsies. Six (11%) children became seizure-free, and 24 (43%) had greater than 50% reduction in seizure frequency. LTG was effective against a broad range of generalized seizure types. Three of 15 patients with Lennox-Gastaut syndrome achieved complete seizure control and eight demonstrated 50 to 99% improvement in seizure control. Increase in seizures (7) and rash (5) were the most common side effects. After valproate was discontinued, LTG therapy was resumed, with no recurrence of rash in any patient. This study suggests that LTG may be a useful drug in the treatment of generalized epilepsies in children.

References

May 23, 1992·Lancet·P L Timmings, A Richens
Nov 14, 1992·Lancet·J StewartE H Reynolds
Jan 1, 1992·European Neurology·P L Timmings, A Richens
May 1, 1992·British Journal of Clinical Pharmacology·A W YuenA W Peck
Jan 1, 1991·Epilepsia·A Richens, A W Yuen
May 1, 1986·Epilepsia·C D BinnieA van Wieringen
Jun 1, 1984·Journal of Neurology, Neurosurgery, and Psychiatry·D ChadwickD M Turnbull
Mar 1, 1995·Seizure : the Journal of the British Epilepsy Association·S J TavernorS W Brown
Aug 1, 1994·Archives of Disease in Childhood·R E Appleton
Nov 12, 1994·Lancet·P VeggiottiO Dulac
Jan 1, 1994·Epilepsia·A Richens
Dec 1, 1993·Neuropediatrics·D BattinoG Avanzini
Apr 1, 1994·Archives of Disease in Childhood·V Manonmani, S J Wallace
May 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·G J SchapelG Davies
Dec 1, 1995·The Journal of Pediatrics·F M BesagG Hosking

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Citations

Dec 7, 2000·Mental Retardation and Developmental Disabilities Research Reviews·J M Pellock, L D Morton
May 11, 2010·Indian Pediatrics·Rahul JainMonica Juneja
Dec 11, 1999·Pediatric Neurology·P S Dimova, R Korinthenberg
Aug 8, 2001·Epilepsia·D N FranzG Sethuraman
Aug 26, 2009·Epilepsia·Patricia E Penovich, L James Willmore
Apr 2, 2009·Neuropsychiatric Disease and Treatment·Kenou van Rijckevorsel
Mar 3, 2010·CNS Drugs·Dean P Sarco, Blaise F D Bourgeois
Feb 18, 2010·CNS Drugs·Aspasia Michoulas, Kevin Farrell
Aug 16, 2001·Brain & Development·S J Wallace
Feb 13, 2009·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Colin D Ferrie, Amit Patel
Jan 1, 1997·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·C D Ferrie, J H Livingston
Jun 14, 2015·BMJ Open·Oluwaseun EgunsolaHelen M Sammons
Jul 29, 2008·Journal of Child Neurology·Jesús Eric Piña-GarzaJohn A Messenheimer

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