PMID: 12752518May 20, 2003Paper

Prospective open-label study of botulinum toxin type B (Myobloc) at doses of 2,400 and 3,000 U for the treatment of glabellar wrinkles

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
Neil S Sadick

Abstract

A previous open-label study evaluated botulinum toxin type B (BTX-B; Myobloc) for the treatment of glabellar wrinkles and showed that it is safe and effective at a dose of 1,800 U. The duration of effect at this dose was approximately 8 weeks, and it was felt that higher doses would result in a longer duration of effect. This is a prospective open-label study to assess the safety, efficacy, and duration of response following BTX-B injection at doses of 2,400 and 3,000 U for the treatment of glabellar frown lines. A total of 39 patients were enrolled: 16 patients received 2,400 U. Eighteen patients received 3,000 U, and 5 patients received saline injections (control group). Doses were divided equally among six sites. All subjects had rapid improvement of interglabellar rhytides, with full response seen within 2 to 3 days. The duration of effect was 9.6 and 10.4 weeks with 2,400 and 3,000 U, respectively. Five subjects (two in the 2,400-U group and three in 3,000-U group) reported adverse events related to the BTX-B injection. Three subjects complained of mild pain at the injection site, and two subjects complained about lid droop/ptosis (one with the occurrence of headache). BTX-B injection is safe and effective for the treatmen...Continue Reading

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Citations

Apr 6, 2004·Facial Plastic Surgery Clinics of North America·A John Vartanian, Steven H Dayan
Sep 12, 2008·The Neurologist·Allison Brashear
Apr 8, 2010·American Journal of Clinical Dermatology·Timothy Corcoran Flynn
Apr 22, 2005·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Leslie BaumannJoy Bryde
Mar 27, 2003·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Neil S Sadick, Alysa R Herman
Jan 24, 2007·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Alastair CarruthersMichael S Leong
Feb 5, 2004·Clinics in Dermatology·Timothy Corcoran Flynn
Oct 22, 2011·Clinics in Dermatology·Jason Emer, Heidi Waldorf
Dec 5, 2009·International Journal of Oral and Maxillofacial Surgery·O W Majid
Oct 4, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·D H LeeK C Moon
May 26, 2004·Clinics in Dermatology·Neil S Sadick
Apr 6, 2004·Atlas of the Oral and Maxillofacial Surgery Clinics of North America·Christopher B Harmon, Michael L Hadley
Apr 24, 2016·Facial Plastic Surgery Clinics of North America·Michael G Neimkin, John B Holds
May 26, 2004·Clinics in Dermatology·Nicholas J Lowe, Paul Yamauchi
Jun 30, 2004·Dermatologic Clinics·Neil S Sadick, Seth L Matarasso

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