Prospective Phase II Trial of Once-weekly Hypofractionated Radiation Therapy for Low-risk Adenocarcinoma of the Prostate: Late Toxicities and Outcomes

Clinical Oncology : a Journal of the Royal College of Radiologists
M ZimmermannCarole Lambert

Abstract

To report the long-term toxicities and sexual quality of life of a once-weekly hypofractionated radiation therapy schedule for low-risk prostate cancer. A multi-institutional phase II trial was conducted, using a three-dimensional conformal radiation therapy (3D-CRT) approach for low-risk prostate cancer (T1a-T2a, Gleason ≤ 6 and prostate-specific antigen ≤ 10 ng/ml). Forty-five Gray (Gy) were delivered in nine fractions of 5 Gy given on a weekly basis. Acute and late genitourinary and gastrointestinal toxicities were graded according to the Radiation Therapy Oncology Group toxicity scale. Sexual function and sexual bother were assessed with the Expanded Prostate Cancer Index Composite (EPIC) questionnaire. Between March 2006 and August 2008, 80 patients were treated, with a median age of 69 years (interquartile range 64-72). The median follow-up was 83 months (interquartile range 73-85 months). At 7 years, overall survival was 88%. No patients died of prostate cancer. Cumulative grade ≥2 genitourinary and gastrointestinal late toxicity was reported for 31.3% and 30% of our patients, respectively. Cumulative grade ≥3 genitourinary and gastrointestinal late toxicity was seen in 3.8% and 12.5% of cases, respectively. Late genitou...Continue Reading

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Citations

Oct 12, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Scott C MorganHoward Sandler
Jul 31, 2019·Current Urology Reports·Soumyajit Roy, Scott C Morgan
May 23, 2019·International Journal of Urology : Official Journal of the Japanese Urological Association·Kazuo HatanoKoichi Konoeda
Sep 1, 2019·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·S Line KrhiliS Supiot
Jun 24, 2021·Revista da Associação Médica Brasileira·Daniel Moore Freitas PalharesArthur Accioly Rosa
Jul 9, 2021·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Selvi DinçerMustafa Halil Akboru

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