Prospective pilot study of high-dose (10 mg/kg/day) liposomal amphotericin B (L-AMB) for the initial treatment of mucormycosis

The Journal of Antimicrobial Chemotherapy
F LanternierFrench Mycosis Study Group

Abstract

Mucormycosis incidence is increasing and is associated with a high rate of mortality. Although lipid-based formulations of amphotericin B are the recommended first-line treatment, only one prospective trial in a limited number of patients has been performed to evaluate this regimen. Patients with proven or probable mucormycosis were included between June 2007 and March 2011. Patients were scheduled to receive 10 mg/kg/day liposomal amphotericin B (L-AMB) monotherapy for 1 month and surgery was performed when appropriate. The primary outcome was response rate at week 4 or at the end of treatment (EOT) if before week 4, evaluated by an independent committee. ClinicalTrials.gov Identifier: NCT00467883. Forty patients were enrolled. Response was analysed in 33 patients at week 4. Most patients had a haematological malignancy as their primary underlying disease (53%). Seventy-one percent of patients underwent therapeutic surgery. The response rate at week 4 or at EOT was 36%, with 18% partial responses and 18% complete responses. The response rate at week 12 was 45%, with 13% partial responses and 32% complete responses. Overall mortality was 38% at week 12 and 53% at week 24. Serum creatinine doubled in 16 (40%) patients and return...Continue Reading

References

Jun 14, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D P KontoyiannisK V Rolston
Sep 20, 2001·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·R HerbrechtL A Pietrelli
Aug 9, 2002·The New England Journal of Medicine·Raoul HerbrechtUNKNOWN Invasive Fungal Infections Group of the European Organisation for Research and Treatment of Cancer and the Global Aspergillu
Feb 21, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Vassiliki SyriopoulouGeorge Saroglou
Aug 5, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Maureen M RodenThomas J Walsh
Apr 20, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Oliver A CornelyUNKNOWN AmBiLoad Trial Study Group
May 9, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ben De PauwUNKNOWN National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group
Jul 22, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Brahm H SegalBen E De Pauw
Jan 24, 2009·Antimicrobial Agents and Chemotherapy·Susanne PerkhoferUNKNOWN European Committee on Antimicrobial Susceptibility Testing
Oct 15, 2009·Medical Mycology·Shmuel ShohamThomas J Walsh
Nov 7, 2009·Postgraduate Medical Journal·A ChakrabartiV Sakhuja
Dec 17, 2009·The Journal of Antimicrobial Chemotherapy·M J G T RüpingO A Cornely
Dec 30, 2009·Antimicrobial Agents and Chemotherapy·Russell E LewisDimitrios P Kontoyiannis
Aug 26, 2010·Emerging Infectious Diseases·Veroniek SaegemanKatrien Lagrou
Jan 5, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A SkiadaUNKNOWN European Confederation of Medical Mycology Working Group on Zygomycosis
Nov 15, 2011·Journal of Clinical Microbiology·Roxana G VitaleGrit Walther
Feb 2, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F LanternierUNKNOWN French Mycosis Study Group
Jun 8, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A XhaardP Ribaud
Oct 24, 2013·Mycoses·Dimitrios P KontoyiannisDavid L Horn
Dec 20, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C LegougeF Dalle
Jan 20, 2015·Annals of Internal Medicine·Kieren A MarrJohan A Maertens

❮ Previous
Next ❯

Citations

Feb 22, 2016·Infectious Disease Clinics of North America·Dimitrios Farmakiotis, Dimitrios P Kontoyiannis
Mar 13, 2016·The Lancet Infectious Diseases·Francisco M MartyUNKNOWN VITAL and FungiScope Mucormycosis Investigators
Apr 18, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A KyvernitakisD P Kontoyiannis
Nov 24, 2016·The Journal of Antimicrobial Chemotherapy·Olivier LortholaryJohn R Perfect
Feb 14, 2017·Future Microbiology·Emma BagshawOliver Andreas Cornely
Mar 23, 2017·International Journal of Pharmaceutics·Ghareb M Soliman
Mar 30, 2017·The Journal of Antimicrobial Chemotherapy·Marie-Pierre LedouxRaoul Herbrecht
Aug 2, 2018·Journal of Fungi·Nikolaos V SipsasDimitrios P Kontoyiannis
Jun 14, 2017·Antimicrobial Agents and Chemotherapy·Marta StanzaniRussell E Lewis
Dec 15, 2018·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Jean-Baptiste Vulsteke, Dries Deeren
Jul 11, 2019·Journal of Fungi·Amanda ChikleyDimitrios P Kontoyiannis
Aug 9, 2019·The Journal of Antimicrobial Chemotherapy·Jon Salmanton-GarcíaUNKNOWN FungiScope® ECMM/ISHAM Working Group
Jan 3, 2018·Journal of the Pediatric Infectious Diseases Society·Joshua R FrancisChristopher C Blyth
Sep 5, 2019·Antimicrobial Agents and Chemotherapy·Frederic Lamoth, Dimitrios P Kontoyiannis
May 19, 2016·Current Opinion in Infectious Diseases·Maria N Chitasombat, Dimitrios P Kontoyiannis
Apr 8, 2020·International Medical Case Reports Journal·Mohsen MeidaniRasoul Mohammadi
Oct 3, 2018·F1000Research·Benoit PilmisFanny Lanternier
Jun 22, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jill Adler-MooreThomas J Walsh
Jun 22, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas J WalshJill Adler-Moore
Nov 28, 2019·Current Infectious Disease Reports·Monica FungGreg E Davis
Mar 15, 2018·Medical Mycology·A SkiadaG Petrikkos
Jan 13, 2018·Current Opinion in Infectious Diseases·José-Artur PaivaJosé Manuel Pereira
Jun 22, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andreas H GrollRoger J M Brüggemann
Oct 13, 2020·Journal of the Pediatric Infectious Diseases Society·William J Steinbach
Sep 16, 2020·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Hanieh ZarghamHarold William Higgins
Jan 31, 2021·Journal of the Neurological Sciences·Cody L NathanJoseph R Berger
Jul 29, 2020·Journal de mycologie médicale·K Brunet, B Rammaert
May 22, 2021·Infectious Disease Clinics of North America·Julie M Steinbrink, Marisa H Miceli
Jun 20, 2021·Revista iberoamericana de micología·María Teresa Martín Gómez, Miguel Salavert Lletí
Jul 7, 2021·African Journal of Urology : the Official Journal of the Pan African Urological Surgeons' Association (PAUSA)·P S SaneeshShalini Pilllai
Jul 10, 2021·Journal of Neurology·François LersyStéphane Kremer
May 18, 2021·Revista iberoamericana de micología·Carolina García-VidalIsidro Jarque
Aug 27, 2021·Therapeutic Advances in Infectious Disease·Mandeep Singh RahiIshmael A Jaiyesimi
Oct 18, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Shuichi ShiraneYuho Najima

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