Prospective Pilot Study of Mirabegron in Pediatric Patients with Overactive Bladder

European Urology
Anne-Sophie BlaisStéphane Bolduc

Abstract

Antimuscarinics are the pharmacologic mainstay of overactive bladder (OAB) management, but side effects limit their use. Mirabegron, a new molecule with a distinct mechanism of action (β3-adrenoreceptor agonist), was recently approved as monotherapy for idiopathic OAB in adults but has not been studied in the pediatric population. To evaluate the efficacy and safety of mirabegron to treat urinary incontinence in children with idiopathic OAB who were refractory to and/or intolerant of antimuscarinics. A prospective off-label study using mirabegron was conducted. Pediatric patients without symptom improvement under behavioral and medical therapies and/or with significant side effects with at least two different antimuscarinic agents were recruited. Our primary outcome was better reported efficacy than with the use of prior anticholinergic medication. Secondary end points were tolerability, safety, and satisfaction. Efficacy and tolerability were assessed with voiding diaries, postvoid residuals, urine cultures, electrocardiogram, and vital signs. Families were questioned for continence, side effects, compliance, and Patient Perception of Bladder Condition (PPBC) questionnaire. The Wilcoxon rank sum test and Wilcoxon signed rank t...Continue Reading

Associated Clinical Trials

Jun 11, 2015·Stéphane Bolduc, Stéphane Bolduc

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Citations

Dec 5, 2016·The Journal of Urology·Fannie MorinStéphane Bolduc
Jan 23, 2017·The Journal of Urology·Paul F Austin
Aug 12, 2016·Journal of Cellular Physiology·Rahul MittalXue Zhong Liu
Jan 16, 2018·F1000Research·Bronagh McDonnell, Lori Ann Birder
Mar 2, 2016·Nature Reviews. Urology·Rebecca Kelsey
Oct 24, 2019·Expert Opinion on Pharmacotherapy·Tiernan Middleton, Pamela Ellsworth
Jan 24, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Armando J LorenzoJoana Dos Santos
Jul 18, 2017·Paediatric Drugs·Paweł Kroll
Aug 15, 2018·World Journal of Urology·Jairam R EswaraMarc Cendron
Oct 5, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Stephen YangPaul Austin
Jul 31, 2019·Current Opinion in Obstetrics & Gynecology·Alla Vash-Margita, Marsha K Guess
Dec 10, 2020·Clinical Medicine Insights. Pediatrics·Magda Rakowska-SilskaBolesław Kalicki
Jun 1, 2021·Paediatric Drugs·Susan J Keam
Aug 18, 2020·Journal of Pediatric Urology·Cristian SagerJuan Pablo Corbetta
Dec 4, 2021·Pediatric Surgery International·Ramesh BabuSugandh Chadha
Dec 8, 2019·Journal of Pediatric Urology·Charlotte Victoria Melling, Anju Goyal
Apr 17, 2021·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Cristian SagerEdurne Ormaechea

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