Prospective predictors of exacerbation status in severe asthma over a 3-year follow-up

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
H KimuraHi-CARAT investigators

Abstract

A predisposition to exacerbations is being recognized as a distinct phenotype with "previous exacerbations" representing the strongest clinical factor associated with future exacerbation. Thus, to identify additional novel biomarkers associated with asthma exacerbations, "past exacerbation status" must be included as a confounding factor. This study aimed to characterize the clinical and biomarker features associated with asthma exacerbations in severe asthma. We evaluated clinical parameters from 105 severe asthmatics yearly for 3 years, as well as their exacerbation status. We classified the subjects into 3 groups: (i) consistent non-exacerbators (CNE, subjects who did not experience any exacerbation over the 3-year period); (ii) consistent frequent exacerbators (CFE, subjects with frequent exacerbation, defined as those who had 2 or more exacerbations within 1 year, throughout the 3-year period); and (iii) intermittent exacerbators (IE). We conducted multivariate analysis for comparisons among the groups for multiple factors, including several Th2-related biomarkers, in addition to the "past exacerbation status." Thirty-nine subjects were classified as CNE, 15 as CFE, and 51 as IE. Frequent exacerbations in the previous year...Continue Reading

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Citations

Aug 31, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G Roberts
Dec 7, 2018·American Journal of Respiratory and Critical Care Medicine·Chloe I BloomPaul Cullinan
Dec 6, 2018·American Journal of Respiratory and Critical Care Medicine·Malcolm R Sears
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Jul 8, 2020·American Journal of Respiratory and Critical Care Medicine·Peter J Sterk, Anirban Sinha
Dec 14, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Graham RobertsJ A Woodfolk
Sep 5, 2020·Lung India : Official Organ of Indian Chest Society·Chandrashekar Y KritiAsha Kamath
Oct 14, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Dong-Woo HanSei Won Lee
Jan 1, 2021·Journal of Asthma and Allergy·Yuki AbeSatoshi Konno
Jun 2, 2020·American Journal of Respiratory and Critical Care Medicine·Michael C PetersLoren C Denlinger
Dec 29, 2020·Current Opinion in Allergy and Clinical Immunology·Claire A Butler, Liam G Heaney
Mar 13, 2021·European Clinical Respiratory Journal·Charlotte Suppli UlrikOle Hilberg
May 1, 2021·International Journal of Molecular Sciences·Emanuela di PalmoAndrea Pession
May 1, 2021·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Soichiro HozawaMasayoshi Koinuma

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