Abstract
To assess, in a Phase I study, whether bladder preservation with concurrent gemcitabine and radiotherapy (RT) influenced patient-reported quality of life (QOL) as determined by the Functional Assessment of Cancer Therapy-Bladder (FACT-BL). Between January 1998 and March 2002, 24 patients with urothelial carcinoma of the bladder were enrolled, and 23 patients underwent transuretheral resection of bladder tumor, followed by twice-weekly gemcitabine with concurrent RT. The initial dose was 10 mg/m2 given twice weekly and increased as tolerated. To assess treatment-related QOL, patients completed the FACT-BL questionnaire. Of the 24 patients enrolled, 23 (96%) were assessed for toxicity and response. The FACT-generic (G) QOL assessment was obtained from 22 (92%) of 23 patients. No statistically significant difference was found in the FACT-G or FACT-BL or the combination before, during, or after treatment. The FACT-BL values were lower in patients who received higher doses of gemcitabine (greater than 20 mg/m2 versus 20 mg/m2 or less). At least one dose-limiting toxicity (DLT) was experienced by 5 (23%) of 22 patients. The FACT-G values were lower for those patients who experienced DLT (difference of -13.1, P = 0.07). The physical w...Continue Reading
References
Jun 1, 1999·Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology·N MiyanagaJ Hinotsu
Apr 6, 2001·Seminars in Surgical Oncology·J DunstW U Shipley
Feb 28, 2002·Journal of Clinical Epidemiology·David CellaDavid H Johnson
Mar 15, 2002·Onkologie·P AlbersUNKNOWN German TCC Study Group of the German Association of Urologic Oncology
Jul 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Claus RödelRolf Sauer
Dec 31, 2002·Expert Review of Anticancer Therapy·Syed A Hussain, Nicholas D James
Apr 4, 2003·Cancer·William U ShipleyUNKNOWN Radiation Therapy Oncology Group
Jun 20, 2003·European Urology·M KuczykUNKNOWN European Society for Oncological Urology
Oct 9, 2003·The Journal of Urology·Anthony L ZietmanWilliam U Shipley
Oct 9, 2003·The Journal of Urology·Michael S CooksonNancy Wells
Citations
Jul 29, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jason A EfstathiouHoward M Sandler
Sep 10, 2011·Therapeutic Advances in Urology·Arjun BalarMatthew I Milowsky
Sep 23, 2009·Current Treatment Options in Oncology·David J Gallagher, Matthew I Milowsky
Oct 1, 2005·Expert Review of Pharmacoeconomics & Outcomes Research·Linda E Carlson, Sheila Garland
Dec 4, 2009·Expert Review of Anticancer Therapy·Faysal A YafiWassim Kassouf
Oct 24, 2012·Critical Reviews in Oncology/hematology·Orazio CaffoEnzo Galligioni
Apr 14, 2010·International Journal of Radiation Oncology, Biology, Physics·Jean-Léon LagrangeUNKNOWN Study Group on Genito-Urinary Tumors
Nov 4, 2008·International Journal of Radiation Oncology, Biology, Physics·Kevin S OhHoward M Sandler
Mar 27, 2007·Seminars in Oncology·Shaneli A Fernando, Howard M Sandler
May 2, 2006·Cancer·Veerasathpurush AllareddyBadrinath R Konety
Jan 26, 2005·International Journal of Radiation Oncology, Biology, Physics·Vijay K SangarRichard A Cowan
Sep 8, 2015·Current Urology Reports·Michael A Feuerstein, Anuj Goenka
Mar 13, 2014·European Urology·Guillaume PloussardWassim Kassouf
Oct 11, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Orazio CaffoAnanya Choudhury
Apr 30, 2017·BJU International·Robert A HuddartEmma Hall
Jan 24, 2019·Health and Quality of Life Outcomes·G A TaarnhøjH Pappot
Sep 9, 2020·Japanese Journal of Clinical Oncology·Tomokazu KimuraHiroyuki Nishiyama
Dec 21, 2004·Expert Review of Anticancer Therapy·Umberto BassoSilvio Monfardini
Mar 3, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Arnold DegboeDavid Cella
Nov 25, 2017·International Journal of Urology : Official Journal of the Japanese Urological Association·Teruo InamotoHaruhito Azuma
Dec 3, 2020·Minerva urologica e nefrologica = The Italian journal of urology and nephrology·Elvira Polo-AlonsoMaria C Mir
May 1, 2021·Journal of Clinical Medicine·Gry Assam TaarnhøjHelle Pappot
May 12, 2021·Current Opinion in Urology·Kristin ZimmermannKeiichiro Mori