PMID: 9169397May 24, 1997Paper

Prospective randomised study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus. DIGAMI (Diabetes Mellitus, Insulin Glucose Infusion in Acute Myocardial Infarction) Study Group

BMJ : British Medical Journal
K Malmberg

Abstract

To test the hypothesis that intensive metabolic treatment with insulin-glucose infusion followed by multidose insulin treatment in patients with diabetes mellitus and acute myocardial infarction improves the prognosis. Patients with diabetes mellitus and acute myocardial infarction were randomly allocated standard treatment plus insulin-glucose infusion for at least 24 hours followed by multidose insulin treatment or standard treatment (controls). 620 patients were recruited, of whom 306 received intensive insulin treatment and 314 served as controls. Long term all cause mortality. The mean (range) follow up was 3.4 (1.6-5.6) years. There were 102 (33%) deaths in the treatment group compared with 138 (44%) deaths in the control group (relative risk (95% confidence interval) 0.72 (0.55 to 0.92); P = 0.011). The effect was most pronounced among the predefined group that included 272 patients without previous insulin treatment and at a low cardiovascular risk (0.49 (0.30 to 0.80); P = 0.004). Insulin-glucose infusion followed by intensive subcutaneous insulin in diabetic patients with acute myocardial infarction improves long term survival, and the effect seen at one year continues for at least 3.5 years, with an absolute reductio...Continue Reading

Citations

Sep 27, 2002·Diabetes/metabolism Research and Reviews·Matthew C Riddle
Nov 13, 2004·Der Internist·A HamannP Nawroth
Apr 7, 2006·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·M LankischStephan Martin
Mar 17, 2009·Basic Research in Cardiology·Ralf DikowLisa Marie Gross
Nov 7, 2009·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Masami HoshinoMotohiro Sakai
Jul 11, 2009·Apoptosis : an International Journal on Programmed Cell Death·Wenjuan XingFeng Gao
Nov 26, 2008·Internal and Emergency Medicine·Chiara LazzeriGian Franco Gensini
Mar 20, 2003·Current Diabetes Reports·D S Bell
Mar 20, 2003·Current Diabetes Reports·Robert L FryeKatherine M Detre
May 24, 2003·Current Diabetes Reports·Pierre Theuma, Vivian A Fonseca
Sep 17, 2003·Current Diabetes Reports·Afshin Sasali, Jack L Leahy
Oct 6, 2004·Current Diabetes Reports·Andrew J Ahmann
Feb 5, 2009·Current Diabetes Reports·Stuart W Zarich
Apr 29, 2010·Current Diabetes Reports·Stuart W Zarich
Apr 29, 2010·Current Diabetes Reports·Ayotunde O Dokun
Nov 17, 2011·Current Diabetes Reports·Ariana Pichardo-Lowden, Robert A Gabbay
Apr 25, 2012·Current Diabetes Reports·Sanjum S SethiMichael E Farkouh
Oct 16, 2012·Current Diabetes Reports·Michelle CareyJoel Zonszein
Nov 30, 2006·Current Heart Failure Reports·Jerry D Estep, David Aguilar
Sep 12, 2000·Current Hypertension Reports·N Mikhail, M L Tuck
Nov 7, 2001·Current Treatment Options in Cardiovascular Medicine·Susanne Trost, Martin LeWinter
Aug 24, 2011·Current Treatment Options in Neurology·Lauren BakerAskiel Bruno
Feb 14, 2013·Journal of Cardiovascular Translational Research·Fabiana RolliniDominick J Angiolillo
Oct 18, 2005·The American Journal of Medicine·John E Gerich
Aug 25, 2009·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Jean A BallwegJames William Gaynor
Dec 13, 2005·International Journal of Cardiology·Uwe Zeymer
Oct 4, 2002·The American Journal of Medicine·Lee N MetchickUNKNOWN Section of Endocrinology, Department of Medicine, Yale Universtiy School of Medicine, New Haven, Connecticut
Oct 4, 2002·The American Journal of Medicine·David M Nathan
Nov 15, 2002·The American Journal of Medicine·Burton E Sobel
Nov 15, 2002·The American Journal of Medicine·William T Cefalu
Nov 15, 2002·The American Journal of Medicine·Kevin A Peterson
Jun 17, 2003·Disease-a-month : DM·Rasa Kazlauskaite, Leon Fogelfeld
Aug 27, 2003·Metabolism: Clinical and Experimental·Irina OtelNicolas Danchin
Jul 1, 1997·Lancet·M W Webster, R S Scott
Aug 3, 2001·Diabetes Research and Clinical Practice·L F Van GaalI H De Leeuw
Feb 1, 2003·Diabetes Research and Clinical Practice·Florentino CarralLuis Escobar

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