Prospective randomised study of long versus short agonist protocol with poor responder patients during in vitro fertilization

Gynécologie, obstétrique & fertilité
K Chatillon-BoissierC Chauleur

Abstract

Different ovarian stimulation protocols are used for in vitro fertilization (IVF) in "poor responder" patients. Our work aims at comparing two ovarian stimulation protocols (long agonist half-dose protocol versus short agonist protocol without pretreatment) in this population of women. This prospective, randomized study was realized at the University Hospital of Saint-Étienne and concerns "poor responder" patients (age between 38 and 42 years and FSH at day 3 more than 9.5 IU/L; and/or antral follicles count less or equal to 6; and/or failure of previous stimulation). The primary endpoint is based on the number of oocytes retrieved at the end of an IVF cycle. Out of the 44 patients randomized, 39 cycles were taken into account (20 in the long protocol, 19 in the short one). At the end of the stimulation (FSH-r 300 to 450 UI/d), the number of follicles recruited appears higher in the long protocol but the difference is not significant (diameter between 14 and 18 mm: 3.0±2.31 vs. 1.88±1.89 and diameter greater than 18 mm: 3.9±2 85 vs. 3.06±2.77). The same tendency is observed for all the following criteria: the number of retrieved oocytes (6.74±2.73 vs. 6.38±4.26), the total number of embryos (3.16±2.03 vs. 2.25±2.11), the pregna...Continue Reading

References

Mar 7, 2003·Fertility and Sterility·James P Toner
Mar 18, 2003·Human Reproduction Update·B C TarlatzisJ Bontis
May 30, 2003·Human Reproduction·D Nikolaou, A Templeton
Feb 12, 2005·Reproductive Biomedicine Online·Julie Galey-FontaineJean-Noël Hugues
May 28, 2005·Human Reproduction Update·Deepti Goswami, Gerard S Conway
Nov 22, 2007·Reproductive Biomedicine Online·Sesh Kamal SunkaraPeter Braude
Jul 29, 2008·Current Opinion in Obstetrics & Gynecology·Dimitris LoutradisPeter Drakakis

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Citations

Apr 4, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Hai-Jing XuYun Sun
Nov 13, 2015·The Cochrane Database of Systematic Reviews·Charalampos S SiristatidisSiladitya Bhattacharya
Feb 5, 2016·Human Reproduction Update·Athanasios PapathanasiouSiladitya Bhattacharya

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