Prospective, Randomized Comparison of the Effect of Two Antimicrobial Regimes on Surgical Site Infection Rate in Dogs Undergoing Orthopedic Implant Surgery

Veterinary Surgery : VS
Miranda J AikenAngus A Anderson

Abstract

To determine whether extending prophylactic antimicrobial administration into the postoperative period would decrease the surgical site infection (SSI) rate in clean canine orthopedic surgery associated with a metal implant. Randomized prospective clinical study. Consecutive procedures (n = 400) on dogs that had clean orthopedic surgery using a metal implant. Cases were randomly allocated to 1 of 2 groups. Group 1 was only administered perioperative antimicrobial drugs whereas group 2 was administered perioperative and 5 days of postoperative antimicrobial therapy. Owners were questioned or dogs were examined at 2 and 6 weeks after surgery to identify any SSI. Long term follow-up by questionnaire of the referring veterinary surgeon ≥1 year after surgery was obtained. Ten of 191 dogs (5.24%) in group 1 developed SSI within 6 weeks compared with 7 of 198 (3.54%) in group 2; 7.22% of dogs in group 1 and 8.24% in group 2 developed infections more than 6 weeks after surgery. SSI rates in this population of dogs were similar where antimicrobial prophylaxis was administered perioperatively over 3 hours or as a course continued for 6 days.

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Citations

Jul 30, 2017·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Tiffany WormhoudtDoreene Hyatt
Jul 19, 2018·Journal of the American Veterinary Medical Association·Daniel J LopezGalina M Hayes
Feb 2, 2019·Veterinary Surgery : VS·Brandy A Burgess
Mar 13, 2021·Veterinary Surgery : VS·Steven C BudsbergGabriella S Sandberg

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