Prospective randomized multicenter study comparing prostate cancer detection rates of end-fire and side-fire transrectal ultrasound probe configuration

Urology
Maximilian RomC Seitz

Abstract

To prospectively test the hypothesis that end-fire transrectal ultrasound prostate biopsy probes have greater cancer detection rates than side-fire probes. Retrospective studies have suggested that such probes might have greater cancer detection rates. The present prospective randomized multicenter trial aimed to compare the prostate cancer detection rates of the end-fire versus side-fire probe configuration during transrectal ultrasound-guided 12-core prostate biopsy. Patients were randomized according to age, prostate-specific antigen level and prostate volume. An interim analysis was planned after the inclusion of 300 patients. At the interim analysis after the inclusion of 297 patients, no differences were found in the mean prostate-specific antigen level (P = .412), mean age (P = .519), mean prostate volume (P = .730), and positive digital rectal examination findings (P = .295). The prostate cancer detection rate did not differ between the end-fire and side-fire probe (34.3% vs 34.4%, P = .972). On multivariate analysis, suspicious digital rectal examination findings (relative risk 8.185, P < .001), prostate-specific antigen level (relative risk 1.051, P = .041), and prostate volume (relative risk 0.973, P < .001), but not...Continue Reading

References

Nov 20, 1997·The Journal of Urology·M E ChenR J Babaian
Apr 24, 2003·Health Technology Assessment : HTA·J DonovanUNKNOWN ProtecT Study Group
Jan 13, 2006·The Journal of Urology·J Stephen JonesCristina Magi-Galluzzi
Apr 7, 2007·European Urology·Guillaume GuichardAlexandre de la Taille
Nov 26, 2008·Urology·Brian J Moran, Michelle H Braccioforte
May 4, 2010·Journal of Endourology·Friedrich AignerFerdinand Frauscher
Nov 9, 2010·European Urology·Axel HeidenreichUNKNOWN European Association of Urology

❮ Previous
Next ❯

Citations

Mar 19, 2014·Current Opinion in Urology·Berrend G MullerJean J de la Rosette
May 3, 2013·World Journal of Urology·James S RosoffStephen J Savage
Apr 15, 2014·The Urologic Clinics of North America·Marc A BjurlinSamir S Taneja
Mar 4, 2014·Journal of Vascular and Interventional Radiology : JVIR·Cheng William HongBradford J Wood
Nov 5, 2013·The Urologic Clinics of North America·Mohamed T Ismail, Leonard G Gomella
Mar 13, 2020·Scandinavian Journal of Urology·Margaretha A van der SlotStijn Roemeling
Oct 14, 2020·The International Journal of Medical Robotics + Computer Assisted Surgery : MRCAS·Jose D Velazco-GarciaNikolaos V Tsekos
Jun 2, 2021·The International Journal of Medical Robotics + Computer Assisted Surgery : MRCAS·Jose D Velazco-GarciaNikolaos V Tsekos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.