Prospective, randomized, single-blind comparison of effects of 6 months of treatment with telmisartan versus enalapril on high-molecular-weight adiponectin concentrations in patients with coronary artery disease

Clinical Therapeutics
Mamoru SatohMotoyuki Nakamura

Abstract

High-molecular-weight (HMW) adiponectin has important antiatherosclerotic properties. This study compared circulating HMW adiponectin concentrations and other parameters between patients with coronary artery disease (CAD) and participants without CAD. We investigated whether treatment with statins and either telmisartan or enalapril might affect HMW adiponectin and other parameters in patients with CAD. Finally, adiponectin concentrations were compared after 6 months of treatment between CAD patients with versus without cardiac events. Consecutive patients with stable CAD admitted to our hospital (Iwate Medical University School of Medicine, Iwate, Japan) for percutaneous coronary intervention (PCI) and stent implantation and with no previous treatment with renin-angiotensin system blockers or statins were recruited. Patients with CAD who met all eligibility criteria were randomly assigned using computer-generated numbers in a 1:1 ratio to receive telmisartan (40 mg/d) or enalapril (5 mg/d) for 6 months. In addition, all patients with CAD were treated with atorvastatin (10 mg/d). The patients without CAD received no treatment with telmisartan, enalapril, or atorvastatin. Plasma concentrations of total and HMW adiponectin were m...Continue Reading

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Citations

Aug 26, 2014·Journal of the American Society of Hypertension : JASH·Hisato TakagiUNKNOWN All-Literature Investigation of Cardiovascular Evidence Group
Feb 23, 2012·International Journal of Cardiology·Hisato TakagiTakuya Umemoto
Jan 13, 2015·Atherosclerosis. Supplements·Lorenzo Arnaboldi, Alberto Corsini
Sep 3, 2010·Current Opinion in Pharmacology·Susan A Phillips, Jacqueline T Kung
Sep 2, 2011·Arquivos brasileiros de endocrinologia e metabologia·Amirhossein Sahebkar
Jan 1, 2014·Environmental Toxicology and Chemistry·Ryan S ProsserPaul K Sibley

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