Prospective Randomized Trial Comparing Mitomycin C Combined with Ologen Implant versus Mitomycin C Alone as Adjuvants in Trabeculectomy.

Ophthalmology. Glaucoma
Mrittika SenTanuj Dada

Abstract

Comparative evaluation of trabeculectomy with mitomycin C (MMC) versus trabeculectomy with MMC plus Ologen (Aeon Astron Europe, Leiden, The Netherlands). Prospective, randomized, comparative study. Fifty eyes of 50 patients with primary open-angle glaucoma or pseudophakic primary angle-closure glaucoma were recruited. Twenty-five eyes underwent trabeculectomy with low-dose MMC alone (0.1 mg/ml for 1 minute; MMC group) and 25 eyes underwent trabeculectomy with low-dose MMC plus Ologen (Ologen group) at a tertiary eye care center. Only patients with minimum follow-up of 12 months were included in the study. Percentage reduction in intraocular pressure (IOP). Secondary outcome measures included percentage of patients achieving absolute and qualified success for IOP of less than 15 mmHg and less than 18 mmHg, bleb morphological features, need for antiglaucoma medications, and rate of complications. The mean preoperative IOP was 25.96±4.82 mmHg and 26.32±4.27 mmHg in the MMC and Ologen groups, respectively (P = 0.81). Mean postoperative IOP at 12 months was 11.33±3.18 mmHg in the MMC group and 14.35±3.34 mmHg in the Ologen group (P < 0.001 at all visits in both the groups). Significantly higher IOP reduction was noted in the MMC gro...Continue Reading

Citations

Jan 11, 2020·Current Opinion in Ophthalmology·Bryan Strelow, David Fleischman
Nov 25, 2020·The British Journal of Ophthalmology·Hsun-I ChiuCatherine Jui-Ling Liu
Apr 20, 2021·Journal of Current Glaucoma Practice·Tanuj DadaShibal Bhartiya
Aug 28, 2021·Diagnostics·Nicoleta AntonIonela Nechita-Dumitriu

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