Prospective relation of adolescent citrate excretion and net acid excretion capacity with blood pressure in young adulthood

American Journal of Physiology. Renal Physiology
Danika KruppThomas Remer

Abstract

Experimental data and observational studies in adults suggest that even subtle changes in acid-base balance, indicative of a higher systemic proton load, are related to higher blood pressure (BP) levels and an increased hypertension risk. However, these associations have not been investigated during growth. The kidney is the central organ in regulating excretion of nonvolatile acids, and renal citrate excretion has been shown to be a sensitive, noninvasive marker of changes in systemic acid balance. We thus analyzed the prospective relation of 24-h citrate excretion, as well as net acid excretion capacity (NAEC; a noninvasive indicator of the renal ability to excrete protons), during adolescence (boys: 10-15 yr; girls: 9-14 yr) with BP levels in young adulthood (18-30 yr) in 374 healthy participants of the Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) Study. In linear-regression analyses adjusted for age, sex, 24-h urinary excretions of sodium and potassium, as well as further relevant confounders, a 1-mmol/1.73 m2/day higher adolescent citrate excretion was related to 1.2 mmHg lower systolic BP ( P = 0.02) but not to diastolic BP ( P = 0.6). A 10-mEq higher NAEC during adolescence was related to 1.7 ...Continue Reading

References

Dec 1, 1966·Analytical Biochemistry·H Moellering, W Gruber
Mar 1, 1983·The American Journal of Physiology·D P Simpson
Jun 19, 2001·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·F ManzS Lange
Oct 22, 2002·American Journal of Physiology. Renal Physiology·Marc MaurerReto Krapf
Mar 3, 2004·European Journal of Nutrition·Anja KrokeMichael J Lentze
Dec 1, 2004·Kidney International·Tiziana MeschiLoris Borghi
Apr 25, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Eric N TaylorGary C Curhan
Sep 1, 2006·American Journal of Hypertension·Carmen A PeraltaMichael G Shlipak
Feb 19, 2008·The British Journal of Nutrition·Kentaro MurakamiUNKNOWN Japan Dietetic Students' Study for Nutrition and Biomarkers Group
Aug 22, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Attilio LositoGaetano Ferrara
Sep 24, 2008·Journal of the American Geriatrics Society·Shoma BerkemeyerThomas Remer
Nov 18, 2008·The American Journal of the Medical Sciences·Wenjie YangUNKNOWN GenSalt Collaborative Research Group
Dec 17, 2008·Metabolic Brain Disease·Giacomo GaribottoMaria Teresa Gandolfo
Sep 2, 2009·Current Genomics·P C B PereiraA C Simões E Silva
Oct 2, 2009·Metabolism: Clinical and Experimental·Shoma Berkemeyer
Dec 17, 2009·The British Journal of Nutrition·Joseph PizzornoJoseph Katzinger
Oct 26, 2010·Urology·Yong-June KimSang-Cheol Lee
Jan 29, 2011·American Journal of Physiology. Renal Physiology·Donald E WessonSimon Sheather
Mar 9, 2011·Pediatrics·Hannelore K NeuhauserAngelika Schaffrath Rosario
Apr 27, 2011·Pediatrics·UNKNOWN Council on Clinical Information Technology
Nov 16, 2011·Human Molecular Genetics·Nicole GrögerThomas Boettger
May 4, 2012·The American Journal of Clinical Nutrition·Marielle F EngberinkJohanna M Geleijnse
Jun 12, 2012·European Journal of Nutrition·Heiner BoeingBernhard Watzl
May 25, 2013·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·H NeuhauserU Ellert
Aug 15, 2013·American Journal of Hypertension·Ernest I MandelEric N Taylor
Sep 21, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Afolarin Amodu, Matthew K Abramowitz
Aug 19, 2015·European Journal of Endocrinology·Guido Di DalmaziMartin Reincke
Sep 28, 2016·The Journal of Clinical Endocrinology and Metabolism·Jonas EscheThomas Remer
Sep 30, 2016·American Journal of Physiology. Renal Physiology·Xuming SunSnezana Petrovic
Apr 8, 2017·Journal of the American Society of Nephrology : JASN·Kalani L RaphaelSrinivasan Beddhu
Aug 31, 2017·Clinical Kidney Journal·Hans PottelLaurence Dubourg

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Citations

Sep 3, 2020·European Journal of Clinical Nutrition·Danika KruppThomas Remer

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Methods Mentioned

BETA
urine collections
urine sample collections
flame atomic absorption spectrometry

Software Mentioned

SAS

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