Prospective single-arm trial of two-week rabeprazole treatment for ulcer healing after gastric endoscopic submucosal dissection

Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society
Keiko NiimiKazuhiko Koike

Abstract

Endoscopic submucosal dissection (ESD) causes artificial ulcers, and there is no consensus regarding the degree of healing in ESD-induced ulcers or the optimal duration of proton pump inhibitor (PPI) treatment. The aim of the present study was to investigate the healing rates of post-ESD ulcers in response to the protective effect of 2-week PPI treatment. Between February 2007 and March 2010, 75 patients/75 lesions and 55 patients/55 lesions were enrolled as interim and per-protocol groups, respectively. All patients were prescribed rabeprazole (10 mg/day) orally for 16 days beginning on the day before ESD. Follow-up endoscopy was carried out 8 weeks after ESD to evaluate ulcer healing. The primary end-point was the healing rate of post-ESD ulcers at 8 weeks after ESD. Secondary end-points were the rate of post-ESD bleeding with emergency endoscopy and the rate of other severe adverse effects during the study period. The transitional rate to scarring-stage ulcers was 80.0% (44/55). Location in the lesser curve and large resected size (>40 mm) were statistically significant predictors for delayed ulcer healing by univariate analysis and the latter was still significant by the multivariate analysis. Post-ESD bleeding occurred wit...Continue Reading

References

Jul 7, 1983·The New England Journal of Medicine·J MesserT C Chalmers
Jul 22, 1998·The American Journal of Gastroenterology·G Treiber, J R Lambert
May 2, 2002·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Takuji GotodaYo Kato
Apr 24, 2003·Gastrointestinal Endoscopy·Akihiro OkanoMitsunobu Matsushita
May 20, 2003·Alimentary Pharmacology & Therapeutics·P MalfertheinerUNKNOWN BYK Advanced Gastric Ulcer Study Group
Jul 28, 2004·Gastrointestinal Endoscopy·Sun-Young LeeJong Chul Rhee
Jul 6, 2006·European Journal of Clinical Pharmacology·Choitsu SakamotoAkira Terano
Sep 26, 2006·Best Practice & Research. Clinical Gastroenterology·Shigeaki YoshidaDaizo Saito
Apr 3, 2007·Digestive Diseases and Sciences·Sisir Kumar Saha
Mar 1, 2008·The Lancet Oncology·Wai K LeungUNKNOWN Asia Pacific Working Group on Gastric Cancer
Dec 23, 2008·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Mitsuhiro FujishiroMasao Omata
Feb 24, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·S OnoM Omata
Aug 18, 2009·Lancet·Peter MalfertheinerKenneth E L McColl

❮ Previous
Next ❯

Citations

Feb 2, 2013·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Mitsuhiro FujishiroHsui-Po Wang
Feb 2, 2013·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Ichiro OdaShigetaka Yoshinaga
Jun 6, 2015·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Yohei HorikawaSyunji Okubo
Feb 24, 2016·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Mitsuhiro FujishiroKazuma Fujimoto
Aug 6, 2016·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Daisuke MaruokaOsamu Yokosuka
Mar 8, 2017·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Izumi TsuchiyaMotoyoshi Izumi
Feb 10, 2017·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Teppei AkimotoNaohisa Yahagi
Jan 24, 2012·World Journal of Gastrointestinal Endoscopy·Yosuke MurakiMasao Ichinose
Oct 22, 2013·Clinical Endoscopy·Chan Hyuk Park, Sang Kil Lee
Aug 4, 2015·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Hiroyuki OnoToshiyuki Matsui
May 26, 2020·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Chan Hyuk ParkHoon Jai Chun
Jul 29, 2016·Alimentary Pharmacology & Therapeutics·T KagawaT Inaba
Jul 29, 2016·World Journal of Gastroenterology : WJG·Yosuke KataokaKazuhiko Koike
Apr 8, 2020·Clinical Endoscopy·Chan Hyuk ParkHoon Jai Chun
Oct 28, 2020·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Hiroyuki OnoKazuma Fujimoto
Aug 17, 2020·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Eri UchidaMotoyoshi Izumi
Oct 14, 2020·Intestinal research·Chan Hyuk ParkHoon Jai Chun

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.