PMID: 6967710Aug 1, 1980Paper

Prospective staging evaluation of patients with cutaneous T-cell lymphomas. Demonstration of a high frequency of extracutaneous dissemination

Annals of Internal Medicine
P BunnJ Minna

Abstract

A prospective pretreatment staging evaluation was done on 49 consecutive patients with mycosis fungoides or the Sézary syndrome to study patterns of disease spread and prognostic factors. Routine staging procedures included complete blood count, blood chemistries, chest roentgenogram, lymphangiogram, radionuclide scans, bone marrow aspiration and biopsy, liver biopsy, and lymph node biopsy. Special evaluations included cytogenetic analysis, electron microscopy, and T-cell cytology. Extracutaneous lymphoma was documented by light microscopy in 51% of patients and by the three special procedures in 88%. Extracutaneous lymphoma was most frequent in blood and lymph nodes; 18% of patients had visceral involvement. Patients with generalized erythroderma had a higher frequency of extracutaneous disease than did patients with cutaneous plaques and tumors by both light microscopy and special studies. Survival was directly related to the type of skin involvement and the presence or absence of extracutaneous disease. Systemic dissemination of cutaneous T-cell lymphoma is frequent, generally asymptomatic, and develops early via the circulation. These findings may explain why cutaneous therapies are associated with a high frequency of relapse.

Citations

Nov 1, 1990·Hematological Oncology·R LiangF Ho
May 15, 2013·Der Pathologe·A C Feller
Sep 1, 1989·Disease-a-month : DM·E R Gaynor, R I Fisher
Jul 30, 1995·International Journal of Radiation Oncology, Biology, Physics·M BeckerS J Knox
Aug 1, 1984·Journal of the American Academy of Dermatology·H S Zackheim
Dec 1, 1995·Blood Reviews·S H KroftL C Peterson
Dec 5, 1998·Seminars in Oncology Nursing·E Samuelson
Jan 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J NicholsG Schwartz
Nov 13, 1980·The New England Journal of Medicine·S D Hsu
Jul 9, 1981·The New England Journal of Medicine
Aug 4, 1983·The New England Journal of Medicine·P A BunnR C Gallo
Oct 1, 1991·British Journal of Haematology·G PapaG Ferranti
May 1, 1990·International Journal of Dermatology·E E Kasha, C M Parker
Jun 1, 1996·International Journal of Dermatology·R M MartíJ M Mascaró
Mar 19, 2016·Case Reports in Ophthalmological Medicine·Sultan S AldreesMiguel N Burnier
Feb 1, 1987·The American Journal of the Medical Sciences·M E Conrad, G A Omura
Sep 1, 1983·International Journal of Radiation Oncology, Biology, Physics·A A TadrosA T Figueredo
Jan 18, 2006·The Journal of Investigative Dermatology·Rakhshandra TalpurMadeleine Duvic
Nov 1, 1988·Gastrointestinal Endoscopy·R GanzL Gordon
Sep 1, 1981·Journal of the American Academy of Dermatology·R L Dobson, P F Nelson
Aug 2, 2006·Clinical Lymphoma & Myeloma·Madeleine DuvicNarin Apisarnthanarax
Nov 1, 1987·Journal of the American Academy of Dermatology·R M KnoblerR L Edelson
Nov 1, 1984·Journal of the American Academy of Dermatology·W L EpsteinS Yuspa
Oct 6, 2004·British Journal of Haematology·Ahmet Dogan, William G Morice
Feb 12, 2009·British Journal of Haematology·Antonino MusolinoAndrea Ardizzoni
Jun 1, 1987·Blood Reviews·K A Foon, R P Gale
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A Engert, V Diehl
Jan 1, 1987·The British Journal of Dermatology·N J SlevinI D Todd
Aug 1, 1982·The British Journal of Dermatology·L HammingaW A Van Vloten
Feb 7, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E C de ConinckR T Hoppe
Nov 1, 1990·Current Problems in Cancer·R T HoppeE A Abel
Jun 1, 1996·Journal of the American Academy of Dermatology·P J van den Anker-LugtenburgE P Krenning
Jan 21, 2014·The Journal of Dermatology·Toshihisa Hamada, Keiji Iwatsuki
Jun 26, 2004·Experimental Dermatology·Sonja ThalerBarbara S Schnierle
Aug 1, 1987·Cancer·C J MerloR S Cox

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.