Prospective studies of gastric secretion in trauma patients

American Journal of Surgery
J F Stremple

Abstract

Patients who had cranial injuries and those who were less severely injured had a normal gastric acid output. Pepsin output decreased throughout the first 72 hours after trauma. Gastric juice protein output was slightly increased. Gastric mucosal cell renewal as estimated by gastric juice DNA was increased. Patients who were more severely injured and those with intra-abdominal trauma had markedly increased gastric acid, pepsin, and protein output after increased gastric mucosal cell exfoliation but a relatively decreased gastric mucosal cell renewal between 36 and 72 hours after trauma. It is concluded that the gastric mucosa must be protected by antacids and/or gastric aspiration before 24 hours after trauma and continued through at least 72 hours. This study supports the importance of acid-pepsin damage during gastric mucosal cell exfoliation and decreased renewal in trauma patients and indicates the timing and value of prophylactic treatment.

References

Mar 1, 1975·Annals of Surgery·C A HubayR P Levy
Apr 1, 1971·Archives of Surgery·C E LucasA J Walt
Feb 1, 1969·Journal of Neurosurgery·C C Watts, K Clark
Sep 20, 1938·The Journal of General Physiology·M L Anson

Citations

Jan 1, 1990·Annals of the New York Academy of Sciences·D E Hernandez
Jan 1, 1990·Annals of the New York Academy of Sciences·G A Mason, D E Hernandez
Jan 1, 1986·American Journal of Surgery·S J MulvihillH T Debas
Jan 1, 1984·American Journal of Surgery·G M LarsonJ D Richardson
Jan 1, 1988·Pediatric Radiology·W H McAlisterE D Tack
Jan 1, 1985·Pediatric Radiology·M E KatzW H McAlister

Related Concepts

Teens
Gastric Juice
Structure of Pyloric Gland
Gastrin
Pepsin 1
Permeability
Secretory Rate
Wounds and Injuries

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