Prospective studies of homocysteine and cardiovascular disease

Nutrition Reviews
P Verhoef, M J Stampfer

Abstract

The link between vascular disease and elevated homocysteine levels has been recognized for more than 30 years, and an association with moderately elevated levels has been suspected for 20 years. The initial investigations were case series, cross-sectional, and case-control studies. Those studies consistently suggest a strong positive relationship between moderate hyperhomocysteinemia and risk of vascular disease. However, a major limitation of these types of study design is that the possibility of elevated homocysteine levels being influenced by the disease or its treatment cannot be ruled out. In case-control studies there is always concern about the appropriateness of the control group. These issues pose much less of a problem in prospective designs. Prospective studies also offer the opportunity to study various manifestations of cardiovascular disease at the same time. However, prospective studies tend to be more expensive and time-consuming, perhaps explaining the smaller number of prospective studies and why the first was not published until 1992. The distinct limitations and advantages of prospective studies are also reviewed.

References

Jul 20, 1989·The New England Journal of Medicine·UNKNOWN Steering Committee of the Physicians' Health Study Research Group
Apr 1, 1995·Journal of Internal Medicine·F LandgrenL Brattström
May 1, 1995·Stroke; a Journal of Cerebral Circulation·A LindgrenB B Johansson
Feb 2, 1995·The New England Journal of Medicine·J SelhubI H Rosenberg
Oct 1, 1994·Stroke; a Journal of Cerebral Circulation·P VerhoefM J Stampfer
Aug 1, 1995·International Journal of Epidemiology·E ArnesenJ E Nordrehaug

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Citations

Jan 14, 1999·The New England Journal of Medicine·R Ross
Dec 21, 2000·Current Atherosclerosis Reports·W G Christen, P M Ridker
Jul 24, 1997·The New England Journal of Medicine·O NygårdS E Vollset
Aug 24, 2018·Journal of Atherosclerosis and Thrombosis·Makoto KinoshitaUNKNOWN Committee for Epidemiology and Clinical Management of Atherosclerosis
Mar 11, 2020·Antioxidants·Armando Alcazar MaganaJan F Stevens
Mar 21, 1998·Current Opinion in Lipidology·P VerhoefE B Rimm
Mar 13, 1999·The American Journal of Clinical Nutrition·R Z Stolzenberg-SolomonL J Appel
Mar 12, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Yoshio MukaiShinzo Tanabe
May 4, 2002·Annals of Epidemiology·Pamela J SchreinerGerardo Heiss
Aug 11, 2021·The Journal of Clinical Endocrinology and Metabolism·Masaki NakanoMasataka Shiraki

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