PMID: 3227962Oct 1, 1988

Prospective studies on a lithium cohort. 2. Renal function. Water and electrolyte metabolism

Acta Psychiatrica Scandinavica
M Schou, P Vestergaard


A cohort of manic-depressive patients given prophylactic lithium treatment were examined before treatment started and at intervals during treatment for up to 7 years. The mean lithium dosage was 23.2 mmol/d and the mean serum lithium concentration 0.68 mmol/l. The treatment did not affect glomerulus function. Urine volume rose by 10-20% and renal concentrating ability fell by 7-10% during the treatment. These changes were markedly smaller than those found in patients treated previously with higher lithium doses and serum lithium concentrations. High urine volumes and low renal concentrating abilities were not more frequent during than before lithium treatment. Complaints of increased thirst, frequent urination, and nycturia were presented more often during than before lithium treatment. Serum concentrations, urinary excretions and renal clearances of sodium and potassium were not altered by the treatment.


Jun 2, 1979·British Medical Journal·R P HullinD B Morgan
Oct 1, 1988·Acta Psychiatrica Scandinavica·P Vestergaard, M Schou
May 1, 1987·Pharmacopsychiatry·M Schou, P Vestergaard
Jul 1, 1986·Comprehensive Psychiatry·P Plenge, E T Mellerup
May 1, 1985·Psychological Medicine·J R KingR P Hullin
Jan 1, 1984·Neuropsychobiology·L SmiganA Wahlin
Apr 1, 1981·Acta Psychiatrica Scandinavica·P Vestergaard, A Amdisen


Sep 1, 1991·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·M Schou
Nov 1, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Janusz K RybakowskiStanislaw Czekalski
Jun 6, 2015·International Journal of Bipolar Disorders·Abed N AzabR H Belmaker
Jan 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·O HetmarT G Bolwig
Feb 18, 2003·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·P Vestergaard, R W Licht
Jun 22, 2001·European Psychiatry : the Journal of the Association of European Psychiatrists·H BendzJ Lanke
Apr 28, 2009·Journal of Psychopharmacology·R PaulC Kelly
Oct 1, 1988·Acta Psychiatrica Scandinavica·P Vestergaard, M Schou
Dec 1, 1989·Acta Psychiatrica Scandinavica·A MuirM L Forsling
Dec 4, 2003·Journal of Clinical Pharmacy and Therapeutics·S Dashti-KhavidakiF Fahimi
Mar 7, 2012·The Australian and New Zealand Journal of Psychiatry·Gin S MalhiMichael Berk
Feb 13, 2014·Human Psychopharmacology·Janusz K RybakowskiStanislaw Czekalski
Apr 2, 2019·Journal of Clinical Psychopharmacology·Milan DastychJana Gottwaldová
Dec 16, 2019·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Tessa S SchootAngèle P M Kerckhoffs

Related Concepts

Manic Disorder
Dose-Response Relationship, Drug
Glomerular Filtration Rate
Kidney Concentrating Ability
Kidney Function Tests
Water-Electrolyte Balance
Incidence Studies

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.