Prospective Study Evaluating Na18F-Positron Emission Tomography/Computed Tomography (NaF-PET/CT) in Predicting Clinical Outcomes and Survival in Advanced Prostate Cancer

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Andrea B ApoloPeter L Choyke

Abstract

This prospective pilot study evaluated the ability of sodium fluoride (Na(18)F) positron emission tomography/computed tomography (NaF-PET/CT) to detect and monitor bone metastases over time and its correlation with clinical outcomes and survival in advanced prostate cancer. Sixty prostate cancer patients, including 30 with and 30 without known bone metastases by conventional imaging underwent NaF-PET/CT at baseline, 6, and 12 months. Positive lesions were verified on follow-up scans. Changes in standardized uptake values (SUV) and lesion number were correlated with prostate-specific antigen (PSA) change, clinical impression, and overall survival (OS). Sixty patients underwent 170 NaF-PET/CT scans. Significant associations included SUV and PSA percent change at 6 (P = 0.014) and 12 months (P = 0.0005); SUV maximal percent change from baseline and clinical impression at 6 months (P = 0.0147) and 6-12 months (P = 0.0053); SUV change at 6 months and OS (P = 0.018); number of lesions on NaF-PET/CT and clinical impression at baseline (P < 0.0001), 6 (P = 0.0078), and 12 months (P = 0.0029); number of lesions on NaF-PET/CT per patient at baseline and OS (P = 0.017). In an exploratory analysis, paired (99m)Tc-MDP bone scans (TcBS) were...Continue Reading

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