Prospective study in 142 cases of hepatitis C virus infection

World Journal of Gastroenterology : WJG
Wen-Mei FanHui Zhuang

Abstract

There is limited information on the natural history of HCV infection in China. We investigated the outcome of HCV infection after nine-year follow-up and the risk factors in blood donors in China in order to provide the foundation for prevention and therapy. A total of 172 cases of HCV infection with anti-HCV positive and ALT abnormality were enrolled in the archives when was screened blood in Hebei Province in 1993. In them 142 blood donors were followed up till July 2002. No antiviral treatment was applied to them during the period of infection. In the present study, anti-HCV, HCV-RNA and aminotransferase were detected and genotyping was conducted by the method of restriction fragment length polymorphism(RFLP). B-type ultrasound detection was performed in all the patients. Age, sex, alcohol consumption and clinical symptoms were questioned. After nine years' follow-up, 10.56% (15/142) of the cases were negative for anti-HCV and 16.42% (12/134) of them were negative for HCV-RNA. The genotypes 1b, 2a and 1b/2a were 91.07%, 6.25% and 2.68% respectively. Twelve cases (8.45%) were negative for both HCV RNA and anti-HCV. The rate of chronicity in this group was 83.58% (112/134), and the rate of viral spontaneous resolution was 16.4...Continue Reading

References

Aug 19, 1999·The New England Journal of Medicine·M J AlterH S Margolis
Jan 6, 2000·Journal of Hepatology·A AlbertiL Benvegnù
Jan 22, 2000·Annals of Internal Medicine·L B SeeffE L Kaplan
Oct 30, 2001·Journal of Hepatology·S Bellentani, C Tiribelli
Oct 31, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jay H Hoofnagle
Oct 31, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Leonard B Seeff

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