Prospective study in a porcine model of sarcoptes scabiei indicates the association of Th2 and Th17 pathways with the clinical severity of scabies

PLoS Neglected Tropical Diseases
K E MounseyJames S McCarthy

Abstract

Understanding of scabies immunopathology has been hampered by the inability to undertake longitudinal studies in humans. Pigs are a useful animal model for scabies, and show clinical and immunologic changes similar to those in humans. Crusted scabies can be readily established in pigs by treatment with the glucocorticoid dexamethasone (Dex). Prospective study of 24 pigs in four groups: a) Scabies+/Dex+, b) Scabies+/Dex-, c) Scabies-/Dex+ and d) Scabies-/Dex-. Clinical symptoms were monitored. Histological profiling and transcriptional analysis of skin biopsies was undertaken to compare changes in cell infiltrates and representative cytokines. A range of clinical responses to Sarcoptes scabiei were observed in Dex treated and non-immunosuppressed pigs. An association was confirmed between disease severity and transcription of the Th2 cytokines IL-4 and IL-13, and up-regulation of the Th17 cytokines IL-17 and IL-23 in pigs with crusted scabies. Immunohistochemistry revealed marked infiltration of lymphocytes and mast cells, and strong staining for IL-17. While an allergic Th2 type response to scabies has been previously described, these results suggest that IL-17 related pathways may also contribute to immunopathology of crusted ...Continue Reading

References

Jun 1, 1986·The American Journal of Dermatopathology·D J Van Neste, M J Staquet
Mar 1, 1995·International Journal of Dermatology·M AmerM el-Harras
May 15, 1993·Lancet·L C MollisonG Marning
Mar 1, 1996·Veterinary Parasitology·L G ArlianD L Vyszenski-Moher
Oct 6, 1997·The Journal of Allergy and Clinical Immunology·C M BraunD M Essayan
Nov 14, 1998·Developmental Immunology·F Ramírez
Jan 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S K Agarwal, G D Marshall
May 2, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S K Agarwal, G D Marshall
Sep 11, 2004·The Journal of Parasitology·Peter N LalliLarry G Arlian
Aug 19, 2007·BMC Molecular Biology·Ann-Britt NygardMerete Fredholm
Apr 29, 2008·Bulletin of the World Health Organization·Danielle B ClucasRoss M Andrews
Sep 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laura McKinleyJay K Kolls
Feb 26, 2010·The New England Journal of Medicine·Bart J Currie, James S McCarthy
Jul 16, 2010·Clinical and Vaccine Immunology : CVI·Shelley F WaltonRobyn O'Hehir
Jul 30, 2010·PLoS Neglected Tropical Diseases·Kate MounseyKatja Fischer
Oct 25, 2011·Diagnostic Microbiology and Infectious Disease·Rama JayarajShelley F Walton
Oct 24, 2012·Trends in Parasitology·Kate E MounseyShelley F Walton
Apr 5, 2013·PLoS Pathogens·Claudia Gonzalez-LombanaPhillip Scott
Aug 14, 2013·PloS One·Marjorie S MorganMichael P Markey
Sep 27, 2013·PLoS Neglected Tropical Diseases·Joshua S DavisBart J Currie
Oct 30, 2013·The Journal of Investigative Dermatology·Roderick J HayMohsen Naghavi
Nov 12, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Julieta PandolfiLourdes Arruvito
Jan 31, 2014·Parasitology·Xiaosong LiuKate Mounsey
Apr 5, 2014·The Journal of Allergy and Clinical Immunology·Susanne KaeslerTilo Biedermann
May 27, 2014·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Jérôme C MartinRégis Josien
Jul 22, 2014·Parasite Immunology·X LiuK E Mounsey

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Citations

Mar 8, 2016·Annales de dermatologie et de vénéréologie·G JouretR Takin
Jun 4, 2016·Parasites & Vectors·Tamieka A FraserScott Carver
Aug 12, 2017·Parasites & Vectors·Sajad A BhatShelley F Walton
Mar 18, 2016·PLoS Neglected Tropical Diseases·Kate E MounseyJames S McCarthy
Nov 19, 2017·Transboundary and Emerging Diseases·J M OldJ Wolfenden
Sep 25, 2019·International Journal of Environmental Research and Public Health·Meng-Huan WuYu-Chieh Lin
Nov 8, 2015·Parasites & Vectors·João CarvalhoEmmanuel Serrano
May 29, 2018·Scientific Reports·Jennifer H KopankeSarah N Bevins
May 8, 2020·Dermatology and Therapy·Yseult SenterreArjen F Nikkels
Mar 15, 2018·BMC Veterinary Research·Alexander GrahoferPetra Roosje
Apr 4, 2021·Vaccines·Simone GarcovichGiampiero Girolomoni
Sep 21, 2021·Parasites & Vectors·Marta ValldeperesJosé Enrique Granados
Dec 20, 2021·Parasite Immunology·Umut GaziKosta Y Mumcuoglu

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Methods Mentioned

BETA
biopsies
scrapings
biopsy
PCR

Software Mentioned

GraphPad
GraphPad Prism
BLASTx
Primer3
Rotor Gene

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