Prospective study of anxiety and incident stroke

Stroke; a Journal of Cerebral Circulation
Maya J LambiaseRebecca C Thurston

Abstract

Higher levels of anxiety are associated with increased risk for coronary heart disease. However, few studies have investigated whether anxiety is associated with stroke risk. The purpose of this study was to examine the association between anxiety symptoms and incident stroke in a nationally representative longitudinal study of the US population. Participants (n=6019) in the First National Health and Nutrition Examination Survey were assessed at baseline and followed for 16.29±4.75 years. Multivariate Cox proportional hazards regression models were used to estimate hazard ratios and 95% confidence intervals of incident stroke associated with a 1 SD increase in anxiety symptoms. Models were adjusted for standard cardiovascular risk factors and additionally for depression. A total of 419 incident stroke cases were identified from hospital/nursing home discharge reports and death certificates. Reporting more anxiety symptoms at baseline was associated with increased risk of incident stroke after adjusting for standard biological and behavioral cardiovascular risk factors (hazard ratio, 1.14; 95% confidence interval, 1.03-1.25). Findings persisted when additionally controlling for depression. Exploratory analyses considering the ro...Continue Reading

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Citations

Apr 1, 2014·Journal of Affective Disorders·Irene Lopez-VilchezAna M Galan
Sep 17, 2014·ILAR Journal·Kristine Coleman, Peter J Pierre
Jun 22, 2015·Journal of Psychosomatic Research·Nicola R SwainKate M Scott
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Jul 17, 2015·International Psychogeriatrics·Henning Schöttke, Claire-Marie Giabbiconi
May 20, 2015·Current Psychiatry Reports·Carmen Andreescu, Daniel Varon
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Sep 4, 2016·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Bernice GulpersFrans Verhey
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Feb 10, 2021·Neurobiology of Aging·Helmet T KarimCarmen Andreescu

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