Prospective study of blood metabolites associated with colorectal cancer risk

International Journal of Cancer. Journal International Du Cancer
Xiang ShuWei Zheng

Abstract

Few prospective studies, and none in Asians, have systematically evaluated the relationship between blood metabolites and colorectal cancer risk. We conducted a nested case-control study to search for risk-associated metabolite biomarkers for colorectal cancer in an Asian population using blood samples collected prior to cancer diagnosis. Conditional logistic regression was performed to assess associations of metabolites with cancer risk. In this study, we included 250 incident cases with colorectal cancer and individually matched controls nested within two prospective Shanghai cohorts. We found 35 metabolites associated with risk of colorectal cancer after adjusting for multiple comparisons. Among them, 12 metabolites were glycerophospholipids including nine associated with reduced risk of colorectal cancer and three with increased risk [odds ratios per standard deviation increase of transformed metabolites: 0.31-1.98; p values: 0.002-1.25 × 10-10 ]. The other 23 metabolites associated with colorectal cancer risk included nine lipids other than glycerophospholipid, seven aromatic compounds, five organic acids and four other organic compounds. After mutual adjustment, nine metabolites remained statistically significant for colo...Continue Reading

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Citations

Jan 22, 2019·International Journal of Cancer. Journal International Du Cancer·Anne J M R GeijsenCornelia M Ulrich
Feb 6, 2019·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M J GunterS J Chanock
Apr 6, 2019·International Journal of Cancer. Journal International Du Cancer·Julie A SchmidtRuth C Travis
Dec 5, 2019·Arquivos De Gastroenterologia·Patricia Valeria Pereira SerafimNora Manoukian Forones
Mar 20, 2020·BioMed Research International·Yi LiuShan-Shan Luo
Sep 22, 2020·BioMed Research International·Yuan-Lin SunYue-Chao Xu
Jan 22, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Tomasz KowalczykCoral Barbas
Jan 29, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M J GunterS J Chanock

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