Prospective study of bone loss in pre- and post-menopausal women on L-thyroxine therapy for non-toxic goitre

Clinical Endocrinology
G De RosaP Caradonna

Abstract

Hyperthyroidism is associated with increased bone turnover and bone resorption, but the effects of suppressive doses of thyroxine in treating non-toxic goitre remain unclear. We carried out a longitudinal study to evaluate the effect on bone of L-thyroxine (L-T4) therapy in women with non-toxic goitre. Forty Caucasian women, 19 of whom were pre-menopausal and 21 post-menopausal, were studied before and after 12 months' L-T4 therapy for non-toxic goitre; 40 women matched for age, body mass index and menopausal status were used as controls. The minimal dosage of L-T4 (mean +/- standard error = 1.5 +/- 0.1 micrograms/kg-1 day-1) was given to each patient to obtain subnormal but detectable serum TSH (< or = 0.2 mU/l). Patients and controls were assessed for minor determinants of bone loss rate, such as genetic and behavioural factors. Bone mineral density (BMD) of the lumbar spine, femoral neck, trochanter and Ward's triangle was measured by dual-energy X-ray absorptiometry at baseline and 12 months; serum and urine markers of bone turnover was measured at baseline, 3, 6 and 12 months. No significant difference was detected in BMD values between patients and controls either at presentation or at the 12-month follow-up. Pre-menopaus...Continue Reading

Citations

Sep 1, 2007·Indian Journal of Clinical Biochemistry : IJCB·V IndumatiRama Jailkhani
Apr 11, 2003·Clinical Implant Dentistry and Related Research·Nikolai J Attard, George A Zarb
Apr 16, 2010·Medicinski pregled·Radoslav PejinLjiljana Todorović-Dilas
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Aug 4, 2007·Endocrinology and Metabolism Clinics of North America·Jason A Wexler, John Sharretts
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