PMID: 11920526Mar 29, 2002Paper

Prospective study of cancer detection in black and white men with normal digital rectal examination but prostate specific antigen equal or greater than 4.0 ng/mL

Cancer
Jackson E FowlerP B Farabaugh

Abstract

The serum prostate specific antigen (PSA) concentration with no clinical evidence of prostate carcinoma is higher and more variable in black than in white American men. The influence of this phenomenon on relations between race, PSA, and cancer detection in men with a PSA greater than or equal to 4.0 ng/mL has not been investigated. Between January 1992 and December 2000, 451 black and 480 white men with a normal digital rectal examination and a PSA greater than or equal to 4.0 ng/mL had an initial prostate biopsy at one medical center. The histology of the biopsy specimens and the Gleason score of malignant specimens was determined by one uropathologist. Cancer was detected in 207 (46%) black and 167 (35%) white men (P = 0.0006). When adjusted for PSA, cancer detection was also greater in the black than the white men, but the difference did not achieve statistical significance (relative risk, 1.30; 95% confidence interval [CI], 0.99-1.71; P = 0.06). Gleason score 7-10 cancer was detected in 88 (20%) black and 45 (9%) white men (P = 0.0001), and the difference remained significant when adjusted for PSA (relative risk, 1.73; 95% CI, 1.16-2.61; P = 0.0008). In the intermediate PSA range of 4.0-9.9 ng/mL, cancer detection and Glea...Continue Reading

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Citations

Jan 19, 2011·Prostate Cancer and Prostatic Diseases·M R SafarinejadS H Safarinejad
Jun 7, 2006·American Journal of Clinical Pathology·M Natalie Grunkemeier, Robin T Vollmer
Mar 1, 2010·Journal of Chiropractic Medicine·Theodore L Johnson
Aug 8, 2006·The Journal of Urology·Brent V YankeIvan Colon
Dec 20, 2003·Journal of Health Psychology·Robert M KaplanDominick L Frosch

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