PMID: 11323318Apr 27, 2001Paper

Prospective study of cataract extraction and risk of coronary heart disease in women

American Journal of Epidemiology
F B HuW C Willett

Abstract

Oxidative damage to proteins in the human lens is believed to be important in the etiology of age-related cataract. Because free radical-mediated oxidative damage to lipoproteins may accelerate atherosclerosis, the authors hypothesized that the development of cataract might be a marker for such damage and therefore might be associated with future risk of coronary heart disease (CHD). The authors followed 60,657 women aged 45--63 years and without known coronary disease, stroke, or cancer in 1984. During 10 years of follow-up (674,283 person-years), the authors documented 887 incident cases of CHD and 2,322 deaths. After adjustment for age, smoking, and other coronary risk factors, cataract extraction was significantly associated with higher risk of CHD (relative risk (RR) = 1.88, 95% confidence interval (CI): 1.41, 2.50) for total CHD, 2.44 (95% CI: 1.54, 3.89) for fatal CHD, and 1.63 (95% CI: 1.14, 2.34) for nonfatal myocardial infarction). The positive association between cataract extraction and total CHD was stronger among women with a history of diabetes (RR = 2.80, 95% CI: 1.77, 4.42) than among those without reported diabetes (RR = 1.51, 95 percent CI: 1.04, 2.18). In multivariate analyses, cataract extraction was associa...Continue Reading

Associated Clinical Trials

May 26, 2000·JoAnn E. Manson, MD

Citations

Jul 16, 2008·Archives of Ophthalmology·Byron L LamKristopher L Arheart
Aug 15, 2003·Ophthalmology·David J LeeD Diane Zheng
Oct 31, 2001·Nutrition·P A LachanceW S Jeong
Mar 27, 2010·Eye·A Y NemetI Kaiserman
Jun 27, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Heike A BischoffWalter C Willett
Jul 11, 2008·Archives of Gerontology and Geriatrics·Robert A Weale
Aug 20, 2005·Journal of the American Geriatrics Society·Gerald McGwinCynthia Owsley
Sep 5, 2013·Colloids and Surfaces. B, Biointerfaces·Pavan SunkireddySubhash C Yadav
Dec 23, 2016·Internal and Emergency Medicine·Chih-Yang HuangWei-Syun Hu
Mar 1, 2006·Stroke; a Journal of Cerebral Circulation·Liang-Kung ChenJanice Hinkle
Jul 5, 2003·Epidemiology·Francine GrodsteinSusan E Hankinson
Jan 27, 2006·Current Opinion in Ophthalmology·Steven Dewey
Aug 2, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Tadanobu YoshikawaNahoko Ogata

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