Prospective study of cigarette smoking and amyotrophic lateral sclerosis

American Journal of Epidemiology
Marc G WeisskopfAlberto Ascherio

Abstract

Cigarette smoking has been proposed as a risk factor for amyotrophic lateral sclerosis (ALS), but because of the low incidence of ALS this association has been examined only with case-control methods. The authors prospectively assessed the relation between cigarette smoking and ALS mortality among participants in the Cancer Prevention Study II cohort of the American Cancer Society, a cohort of over 1 million people enrolled in 1982 who completed a lifestyle questionnaire including a detailed smoking history at baseline. Causes of deaths were ascertained through death certificates; ALS was not identified separately until 1989. From January 1, 1989, through 1998, 291 women and 330 men died from ALS. The relative risk of ALS among current smokers compared with never smokers was 1.67 (95% confidence interval: 1.24, 2.24; p = 0.002) in women and 0.69 (95% confidence interval: 0.49, 0.99; p = 0.04) in men. The difference in the relative risk estimates between the sexes was statistically significant (p < 0.0003). This large prospective study provides limited evidence that current cigarette smoking may be associated with increased death rates from ALS in women but not in men.

Citations

Nov 6, 2004·Annals of Neurology·Alberto AscherioMichael J Thun
Dec 20, 2005·Journal of Neurology·J A RochaJ Mendes Ribeiro
Dec 17, 2009·Journal of Neurology·Alain FurbyVéronique Sébille
Jun 19, 2007·Lancet·J D Mitchell, G D Borasio
Apr 22, 2010·American Journal of Epidemiology·Fang FangFreya Kamel
May 14, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·P SundströmG Hallmans
Apr 18, 2009·Journal of Neurology, Neurosurgery, and Psychiatry·M G WeisskopfA Ascherio
Dec 1, 2007·Occupational and Environmental Medicine·H Checkoway
Aug 17, 2005·Neuroepidemiology·D Michal FreedmanRalph W Kuncl
Mar 2, 2012·Neuroepidemiology·Roger Pamphlett, Elizabeth Cochran Ward
Feb 5, 2009·Orphanet Journal of Rare Diseases·Lokesh C Wijesekera, P Nigel Leigh
Oct 25, 2011·American Journal of Public Health·Paul A SchulteHeeKyoung Chun
Jul 26, 2011·Neurology International·Aline Furtado BastosVictor Hugo Bastos
Aug 23, 2012·North American Journal of Medical Sciences·Kamalesh DasMrinalkanti Ghosh
Sep 15, 2009·Environmental Health Perspectives·Fang FangFreya Kamel
May 13, 2014·American Journal of Epidemiology·Elinor FondellAlberto Ascherio
Apr 15, 2014·Neurochemistry International·Akshay AnandKeshav Thakur
Mar 22, 2006·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Guido R Zanni, Jeannette Y Wick
May 31, 2008·American Journal of Public Health·Keson TheppeangBrian S Schwartz
Jul 14, 2012·American Journal of Epidemiology·Sonja W de JongLeonard H van den Berg
Aug 15, 2013·American Journal of Epidemiology·Elinor FondellAlberto Ascherio
Jan 31, 2016·American Journal of Epidemiology·Ryan M SealsMarc G Weisskopf
Mar 6, 2009·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Ceryl A HarwoodPamela J Shaw
Feb 26, 2014·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Hiroshi MitsumotoUNKNOWN ALS COSMOS Study Group
Nov 9, 2012·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Éilis J O'ReillyAlberto Ascherio
May 25, 2013·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Pam Factor-LitvakAndrew Eisen
Jun 20, 2013·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Elinor FondellAlberto Ascherio
Sep 14, 2007·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Liliana Olim Gouveia, Mamede de Carvalho
Aug 9, 2012·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Elinor FondellAlberto Ascherio
Jan 5, 2011·Gender Medicine·Pamela A McCombe, Robert D Henderson
Feb 5, 2010·Journal of the Neurological Sciences·Silke SchmidtEugene Z Oddone
Aug 20, 2010·Journal of Neuropathology and Experimental Neurology·Ann C McKeeAndrew E Budson
Jun 16, 2009·Revue neurologique·M-H Soriani, C Desnuelle
Mar 31, 2015·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Elinor FondellAlberto Ascherio
Apr 29, 2009·Annals of Neurology·Valentina GalloElio Riboli
Apr 29, 2009·Annals of Neurology·Marc G Weisskopf, Alberto Ascherio
Mar 11, 2005·Neurologic Clinics·Matthew P Wicklund
Jun 26, 2013·Free Radical Biology & Medicine·Emanuele D'AmicoHiroshi Mitsumoto
Mar 1, 2006·Biochimica Et Biophysica Acta·Francois Gros-LouisGuy A Rouleau
Oct 31, 2006·Biochimica Et Biophysica Acta·Ettore BeghiUNKNOWN EURALS Consortium
Apr 7, 2009·Environmental Health : a Global Access Science Source·Naila KhalilJane A Cauley

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.