Prospective study of colonization and infection because of Pseudomonas aeruginosa in mechanically ventilated patients at a neonatal intensive care unit in China

American Journal of Infection Control
Hong-bo HuXing-yun Lei

Abstract

Ventilator-associated pneumonia (VAP) is an important nosocomial infection at neonatal intensive care units (NICU), frequently caused by Pseudomonas aeruginosa. A 6-month prospective study from January 2009 through June 2009 was performed to investigate the respective contribution of endogenous and exogenous transmission of P aeruginosa in the respiratory colonization or/and infection in the mechanically ventilated patients at a NICU to identify routes of lung infection with P aeruginosa and to assess risk factors for colonization or respiratory infection with P aeruginosa. Samples from oropharyngeal swab, tracheobronchial aspirates, gastric aspirate, and rectal swab were obtained in each patient after intubation and then twice a week. Surveillance cultures for the presence of P aeruginosa from environmental surfaces of the ICU were taken once every 5 days during the study period. Pulsed-field gel electrophoresis was used to characterize the clonal relatedness of the strains by SpeI-digested genomic DNA. Eighteen patients (78.3%) had colonization of the upper respiratory tract. Sixteen (69.6%) patients with colonization of the respiratory tract were infected from other patients or environmental surfaces, which was considered ex...Continue Reading

References

Oct 1, 1995·American Journal of Respiratory and Critical Care Medicine·M Orozco-LeviR Rodriguez-Roisin
Feb 26, 1998·American Journal of Respiratory and Critical Care Medicine·J L TrouilletC Gibert
May 16, 2007·Intensive Care Medicine·Antonella AgodiCarmelo Denaro
Aug 21, 2008·Intensive Care Medicine·Evangelos PapadomichelakisHelen Giamarellou
Jul 11, 2009·The Journal of Trauma·Erika L RangelJoseph S Solomkin

❮ Previous
Next ❯

Citations

Feb 19, 2013·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Julio Cesar Medina-PresentadoGloria Rieppi
Sep 18, 2012·Community Dentistry and Oral Epidemiology·M TellezA I Ismail

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.

Carbapenems

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Carbapenems (ASM)

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Biofilms

Biofilms are adherent bacterial communities embedded in a polymer matrix and can cause persistent human infections that are highly resistant to antibiotics. Discover the latest research on Biofilms here.