PMID: 6413667Jan 1, 1983Paper

Prospective study of fatty acid supplementation over 3 years in patients with cystic fibrosis

Journal of Pediatric Gastroenterology and Nutrition
E KusoffskyS Troell

Abstract

Intravenous fatty acid supplementation (10% Intralipid, 10 ml/kg body weight) was given to 10 patients with cystic fibrosis (CF), in intervals for 3 years. One year of intensive treatment with supplementation every fortnight was followed by 1 year of intermission and then 1 year of the same treatment given for 2 days every 2 months. Compared with matched CF patients, the clinical course, evaluated by Shwachmann scoring, showed less deterioration in the treated group, especially during the year of intensive treatment. Single parameters, such as pulmonary function tests, pulmonary X-ray films, clinical infections, bacterial growth of sputa, and sweat electrolyte concentration, showed no differences. It is concluded that if there is any benefit of this kind of treatment in CF, it has to be very intensive. At present, the psychological stress involved in repeated parenteral administrations over long periods prevents its use in clinical routine.

Citations

Apr 28, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·C DoughneyR L Dormer
Sep 1, 1987·Archives of Disease in Childhood·A E HollsingB Strandvik
Nov 1, 1987·Gut·P L Zentler-Munro
Aug 3, 2010·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Birgitta Strandvik
Jun 28, 2005·Pharmacotherapy·William A Prescott, Cary E Johnson
Mar 18, 1999·Baillière's Clinical Gastroenterology·D Turck, L Michaud
Sep 1, 1996·Prostaglandins, Leukotrienes, and Essential Fatty Acids·A Christophe, E Robberecht
Oct 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A LindbladB Strandvik
Aug 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A LindbladB Strandvik
Dec 2, 2000·Current Opinion in Pulmonary Medicine·S D FreedmanJ G Alvarez
Jan 1, 1985·Acta Paediatrica Scandinavica. Supplement·J A Dodge
Apr 4, 2021·International Journal of Molecular Sciences·Birgitta Strandvik
Oct 1, 1987·Journal of Clinical Microbiology·A E HollsingB Strandvik

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